Sökning: "differential regulation"
Visar resultat 1 - 5 av 210 avhandlingar innehållade orden differential regulation.
1. Novel endogenous mechanisms of complement regulation - A delicate balance
Sammanfattning : In this thesis, the biochemical mechanisms for complement activation by endogenous proteins are explored. The short leucine-rich repeat proteins (SLRPs) help organise extracellular matrices. We found that several SLRPs bind C1q and of these, fibromodulin and osteoadherin trigger complement. LÄS MER
2. Allosteric regulation of synaptic processes
Sammanfattning : Glutamatergic neurotransmission is of key importance for short-term and long-term plasticity in the hippocampus, a part of the medial temporal lobe which is responsible for processes of explicit semantic and spatial memory. Short-term plasticity is mainly regulated by the presynaptic neuron and long-term plasticity is to large parts regulated by the post-synaptic neuron. LÄS MER
3. Calreticulins- Calcium-Binding Proteins with Functional Diversity and Evolutionary Duality
Sammanfattning : Calreticulin is a multifunctional protein mainly localized in the endoplasmic reticulum in eukaryotic organisms, except yeasts. The protein comprises three distinct regions: the N-terminal N domain, the C-terminal C domain, and the central P domain, reflecting the functional diversity of calreticulin. LÄS MER
4. Tolerance Mechanisms in Collagen-Induced Arthritis an Animal Model of Rheumatoid Arthritis
Sammanfattning : Collagen-induced arthritis (CIA) is one of the most commonly used animal models for Rheumatoid arthritis (RA). CIA is induced in susceptible mouse strains after immunization with heterologous type II collagen (CII). In mice of the H-2q haplotype rat CII (rCII) is used whereas in mice of the H-2r haplotype bovine CII is utilized. LÄS MER
5. Contributions to Statistical Analysis of Gene Expression Data
Sammanfattning : .... LÄS MER