Sökning: "Ribonucleotide Reductase"
Visar resultat 1 - 5 av 72 avhandlingar innehållade orden Ribonucleotide Reductase.
Sammanfattning : In all bacterial, plant and animal cells, as well as in many viruses, genetic information resides in DNA (deoxyribonucleic acid). Replication of DNA is essential for proliferation, and DNA-containing viruses (such as herpesviruses) must carry out this process within the mammalian cells they infect. LÄS MER
Sammanfattning : A prerequisite for a multicellular organism to survive is the ability to correctly replicate and repair DNA while minimizing the number of heritable mutations. To achieve this, cells need a balanced supply of deoxyribonucleoside triphosphates (dNTPs), the precursors for DNA synthesis. LÄS MER
Sammanfattning : The stability of biological life over time requires that the integrity of the genetic material of an organism, the genome, be maintained as it is passed on from one generation to the next. All known cellular life has DNA-based genomes, which are duplicated before each cell division in a process called replication. LÄS MER
4. Class I Ribonucleotide Reductases : overall activity regulation, oligomerization, and drug targeting
Sammanfattning : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. LÄS MER
Sammanfattning : Ribonucleotide reductase (EC 1.17.4) catalyses the enzymatic reduction of ribonucleotides to their corresponding deoxyribo- nucleotides, the monomeric precursors for the DNA synthesis in all living cells. All ribonucleotide reductases so far Isolated from different species have been found to contain metal ions, either iron, cobolt or manganese. LÄS MER