Sökning: "CK2"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet CK2.

  1. 1. Post-translational modifications in DNA base excision repair : The roles of CK2 and PARP-1

    Författare :Cecilia Ström; Thomas Helleday; Hans Krokan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; base excision repair; single-strand break repair; PARP-1; CK2; XRCC1; mammalian cells; Cell and molecular biology; Cell- och molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Base lesions and DNA single-strand breaks (SSBs) are very common types of DNA damage. The base excision repair (BER) and single-strand break repair (SSBR) machineries both require a succession of enzymatic events in order to remove these types of endogenous lesions and to restore the DNA. LÄS MER

  3. 2. Post-translational modifications of XRCC1 by the protein kinase CK2

    Författare :Cecilia Ström; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 3. Studies of calcium binding proteins 1 and 2 and protein kinase CK2

    Författare :Inger Janson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; calcium binding protein 1; calcium binding protein 2; calcium binding protein 4; erd2receptor; protein kinase CK2; endoplasmic reticulum; Golgi; microsomes; heparin; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : The endoplasmic reticulum (ER) is a major intracellular compartment of eukaryotic cells and is the site of the synthesis and post-translational modification of both secretory and membrane glycoproteins. Upon cell rupture vesicles of several kinds are formed from cell membranes, mainly derived from ER and are called microsomes. LÄS MER

  5. 4. Mechanisms of Wnt signaling : from embryonic stem cells to dopaminergic neurons

    Författare :Lukas Cajanek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ability of a cell to respond in a specific way to certain signals represents key biological phenomena governing development of multicellular organism. Cellular signaling regulates all aspects of cell biology such as proliferation, migration, differentiation, and death. LÄS MER

  7. 5. Free-energy studies of ligand-binding affinities

    Författare :Vilhelm Ekberg; Beräkningskemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; free energy perturbation; drug design; ligand-binding affinity; entropy; molecular mechanics; molecular dynamics;

    Sammanfattning : In drug discovery, it is of utmost importance to accurately calculate the free energies of binding ligands to various protein targets, such as enzymes and receptors. We have assessed and used computational tools for this aim, most of them based on molecular dynamics (MD) simulations. LÄS MER