Sökning: "DNA repair enzyme"
Visar resultat 11 - 15 av 53 avhandlingar innehållade orden DNA repair enzyme.
11. The DNA repair enzymes MTH1 and OGG1 as targets to treat inflammation
Sammanfattning : Chronic and acute inflammatory diseases, such as multiple sclerosis (MS), psoriasis and sepsis, account for vast disability and morbidity in the world. Several new immunomodulating treatment alternatives have been developed over the past decades, but there is still an urgent need for new options. LÄS MER
12. Unwrapping the role of WRAP53β in DNA damage response
Sammanfattning : WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the telomerase enzyme to Cajal bodies, as well as targeting of the E3 ligase RNF8 to DNA double-strand breaks (DSBs). LÄS MER
13. Regulation of ongoing DNA synthesis in normal and neoplastic brain tissue
Sammanfattning : The treatment of human brain tumour is challenging in part due to the blood brain barrier and in part due to the specific biology of brain tumours that confer resistance to chemotherapy. For instance, the 5 years survival rate for patients carrying intracranial glioblastoma multiforme has remained at 4-5 % for the last 30 years. LÄS MER
14. General stress proteins: Novel function and signals for induction of stationary phase genes in E.coli
Sammanfattning : Survival during conditions when nutrients become scarce requires adaptation and expression of genes for maintenance in order for the cell to survive. Among the numerous proteins involved in adaptation and regulation under these conditions, the stationary phase sigma factor, σS, and the Universal stress proteins contribute to survival and bestow the cell with general stress protective functions during growth arrest. LÄS MER
15. Mechanisms controlling DNA damage survival and mutation rates in budding yeast
Sammanfattning : All living organisms are made of cells, within which genetic information is stored on long strands of deoxyribonucleic acid (DNA). The DNA encodes thousands of different genes and provides the blueprint for all of the structures and activities occurring within the cell. LÄS MER