Sökning: "DNA repair enzyme"

Visar resultat 6 - 10 av 53 avhandlingar innehållade orden DNA repair enzyme.

  1. 6. Quantum Chemical Studies of Protein-Bound Chromophores, UV-Light Induced DNA Damages, and Lignin Formation

    Författare :Bo Durbeej; Leif Eriksson; Tim Clark; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quantum chemistry; quantum chemistry; calculations; density functional theory; excited states; photochemistry; chromophores; absorption spectra; bathochromic shift; isomerization; UV radiation; DNA damages; cycloaddition reactions; photoenzymic repair; electron transfer; lignin; polymerization; phenoxy radicals; dilignols; Kvantkemi; Quantum chemistry; Kvantkemi;

    Sammanfattning : Quantum chemical methods have been used to provide a better understanding of the photochemistry of astaxanthin and phytochromobilin; the photoenzymic repair of UV-light induced DNA damages; and the formation of lignin. The carotenoid astaxanthin (AXT) is responsible for the colouration of lobster shell. LÄS MER

  3. 7. Intelligent Nucleic Acid Interactions with Peptide Nucleic Acid (PNA) and Recombination Enzyme RecA

    Författare :Pernilla Wittung; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fluorescence; RecA; homologous recombination; circular dichroism; DNA analogs; -anti-BPDE; spectroscopy; PNA; DNA-protein interactions;

    Sammanfattning : The work presented in this thesis focuses on interactions between nucleic-acids in biological systems, particularly interactions of the promising drug-candidate peptide nucleic acid (PNA), and on protein-DNA intermediates during recombination. Several experimental techniques, mainly circular dichroism and fluorescence spectroscopy, have been used to characterize the interactions of interest. LÄS MER

  4. 8. Influence of genetic polymorphisms on DNA repair, p53 mutations and cancer risk

    Författare :Charlotta Ryk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :polymorphisms; metabolism; DNA repair; p53; lung cancer; bladder cancer;

    Sammanfattning : Individuals have different susceptibility towards environmental exposures that may cause or contribute to disease. This inter-individual variation is partly due to genetic polymorphisms in genes involved in DNA repair and metabolism, which have potential to modulate the function of the encoded proteins. LÄS MER

  5. 9. Computational chemistry studies of UV induced processes in human skin

    Författare :Jonas Danielsson; Aatto Laaksonen; Villy Sundström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Photochemistry; Theoretical chemistry; Density functional theory; UV effects; TD-DFT; enzyme catalysis; DNA damage; Molecular dynamics; Physical chemistry; Fysikalisk kemi;

    Sammanfattning : This thesis presents and uses the techniques of computational chemistry to explore two different processes induced in human skin by ultraviolet light. The first is the transformation of urocanic acid into a immunosuppressing agent, and the other is the enzymatic action of the 8-oxoguanine glycosylase enzyme. LÄS MER

  7. 10. Towards Novel Biomarkers for Low-grade Glioma

    Författare :Shala Ghaderi Berntsson; Anja Smits; Peter Siesjö; Uppsala universitet; []
    Nyckelord :Low-grade glioma; prognosis; epilepsy; PROX1; DNA repair enzyme; PET; Physiological MRI; Neuroscience; Neurovetenskap;

    Sammanfattning : Gliomas are common primary brain tumours that occur as low-grade (LGG) and high-grade gliomas (HGG). Typically occurring in younger adults, LGG has an indolent course with a median survival of 5-10 years, but carries an inherent potential for transforming into HGG. LÄS MER