Sökning: "DNA repair enzyme"

Visar resultat 21 - 25 av 53 avhandlingar innehållade orden DNA repair enzyme.

  1. 21. From quality control to neurodegeneration : regulation of autophagy and the DNA damage response by ubiquitin-modifying enzymes

    Författare :Laura K Herzog Croona; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein homeostasis and genome integrity are safeguarded by a variety of cellular quality control pathways. While protein quality is controlled by a delicate balance between protein biosynthesis, folding and degradation, the DNA is subject to tightly regulated surveillance processes that sense, signal and repair DNA lesions. LÄS MER

  3. 22. Emerging roles of PFKFB3 and CX3CR1 in the DNA damage response and their potential as therapeutic targets in cancer

    Författare :Anna Huguet Ninou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genomic instability in cancer is exploited therapeutically using DNA damaging therapies that cause irreparable lesions above the threshold of tolerable DNA damage levels. Nevertheless, toxic side effects on healthy tissues limit the therapeutic potential of such therapies. LÄS MER

  4. 23. Effects of increased UV-B radiation on the lichen Cladonia arbuscula spp. mitis: UV-absorbing pigments and DNA damage

    Författare :Roberta Buffoni Hall; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Systematic botany; taxonomy; morphology; phytogeography; chemotaxonomy. Physiology of nonvascular plants; kemotaxonomi. Växters fysiologi inte kärlväxter .; Systematisk botanik; taxonomi; morfologi;

    Sammanfattning : Lichens, a form of symbiosis between a fungal and a photosynthetic partner, are believed to be a group that evolved early in the history of terrestrial life. As a consequence, they probably experienced higher ultraviolet (UV) radiation fluxes than at present. LÄS MER

  5. 24. The telomere binding proteins in yeast and their role in telomere maintenance

    Författare :Cecilia Gustafsson; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Telomeres are the end-structures of linear chromosome which are crucial for maintaining genome integrity. The telomeres prevent the DNA-repair machinery from recognizing the chromosome ends as double-strand breaks and from end-to-end fusions. LÄS MER

  7. 25. Allosteric Regulation and Radical Transfer in Ribonucleotide Reductase

    Författare :Karl-Magnus Larsson; Pär Nordlund; Derek Logan; Roger Kornberg; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allosteric regulation; substrate specificity; ribonucleotide reductase; radical; Biochemistry; Biokemi;

    Sammanfattning : The stability of biological life over time requires that the integrity of the genetic material of an organism, the genome, be maintained as it is passed on from one generation to the next. All known cellular life has DNA-based genomes, which are duplicated before each cell division in a process called replication. LÄS MER