Sökning: "DISSECT."

Visar resultat 1 - 5 av 109 avhandlingar innehållade ordet DISSECT..

  1. 1. Species Delimitation and Phylogenetic Relationships. A study of Silene sections Atocion and Cryptoneurae

    Författare :Zeynep Aydin; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Caryophyllaceae; Silene; Section Atocion; S. ertekinii; S. cryptoneura; S. aegyptiaca; SystematicsPhylogenetics; Species delimitation; Multispecies coalescent; Marginal likelihood; Species tree; DISSECT.;

    Sammanfattning : Abstract The existence of conflicting genealogies of different genes through the evolution of species complicates the inference of phylogenetic relationships. The Multispecies Coalescent (MSC) model provides a theoretical background that account for the stochasticity in the genealogical process, thus providing systematists with a potentially objective way of testing alternative hypotheses of putative species. LÄS MER

  3. 2. Genetic characterization to dissect the phenotypic complexity of autoimmunity

    Författare :Jenny C Karlsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serologi; serology; epistasis; EAE; autoimmunity; Immunology; CIA; QTL;

    Sammanfattning : Autoimmune diseases are dependent on multiple genes and unknown environmental factors. Great efforts in the identification of genes conferring susceptibility to autoimmune diseases like Rheumatoid Arthritis (RA) and Multiple Sclerosis (MS) have recently been rewarding. LÄS MER

  4. 3. Genomic selection and genome-wide association studies to dissect quantitative traits in forest trees

    Författare :Biyue Tan; Pär K. Ingvarsson; Björn Sundberg; Harry X. Wu; Dario Grattapaglia; Xiao-Ru Wang; Leopoldo Sanchez; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Genomic prediction; genome-wide association study; additive effects; dominance effects; epistasis effects; realized relationship matrix; Eucalyptus grandis; Eucalyptus urophylla;

    Sammanfattning : The convergence of quantitative genetics of complex traits with genomic technologies is quickly becoming an innovative approach to explore fundamental genetic questions and also have practical consequences for implementations in tree breeding. In this thesis, I used genomic selection and genome-wide association studies (GWAS) to dissect the genetic basis of quantitative traits, i. LÄS MER

  5. 4. A sub-phenotype approach to dissect the genetic control of murine type 1 diabetes

    Författare :Marie-Louise Bergman; Leif Andersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes (T1D). The disease in the NOD mouse is polygenic and multifactorial and so far at least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified. However, no etiological mutations have been definitely ascribed to the Idd loci. LÄS MER

  7. 5. Functional genomics approaches to dissect causal DNA variations in obesity and type 2 diabetes

    Författare :Mi Huang; Genetisk och molekylär epidemiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; Obesity; Type 2 diabetes; CRISPR Cas9; precision medicine; adipocytes; functional genomics;

    Sammanfattning : GWAS studies have identified hundreds of loci that associate with obesity and type 2 diabetes. However, the functional relevance of the genetic variants, and their impact on disease or traits, is largely unknown. LÄS MER