Sökning: "Cryo-electron microscopy"

Visar resultat 21 - 25 av 37 avhandlingar innehållade orden Cryo-electron microscopy.

  1. 21. Biochemical and structural studies of proteins supporting the genome replication of enteroviruses and Giardia intestinalis

    Författare :Kasturika Shankar; Lars-Anders Carlson; Daniel Hurdiss; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Structural Biology; Membrane reconstitution; Infectious diseases; Virus; Protozoa; Infectious Diseases; infektionssjukdomar; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The Enterovirus genus of the Picornaviridae family includes non-enveloped, positive-sense single-stranded RNA (ssRNA) viruses. This genus of viruses causes many diseases such as poliomyelitis by poliovirus (PV), cardiomyopathy by coxsackievirus B3 (CVB3), common cold by rhinoviruses (RVs) and meningitis by Enterovirus 71 (EV 71). The 7. LÄS MER

  3. 22. Understanding structure and function of membrane protein transporters

    Författare :Anna-Karin Lundbäck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Membrane protein transporters are important proteins in the cell, as they maintain different solutes and metabolites at a stable concentration. Numerous diseases can be linked to malfunctioning transporters, which makes them interesting pharmaceutical targets. LÄS MER

  4. 23. Macromolecular organization of the chikungunya virus replication organelle

    Författare :Timothée Laurent; Lars-Anders Carlson; Richard Lundmark; Alex Evilevitch; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The chikungunya virus is a positive-sense RNA virus responsible for the crippling chikungunya fever. It is transmitted through the bites of two species of mosquitoes: Aedes aegypti and Aedes albopictus. LÄS MER

  5. 24. Small Particles with Big Impact : Structural Studies of Viruses and Toxicological Studies of Nanodiamonds

    Författare :Anna Munke; Marvin Seibert; Kenta Okamoto; Filipe Maia; Inger Andersson; Nicola Stonehouse; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chaetenuissarnavirus II; cryo-EM; CtenRNAV-II; Escherichia coli; Danio rerio; flash X-ray imaging; Marnaviridae; single-particle analysis; single-particle imaging; Sogarnavirus; virus evolution; virus structure; XFEL; zebrafish embryo; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Sammanfattning : Nanoparticles (NPs) can be found everywhere and their existence has both beneficial and harmful consequences for the environment and living beings. The investigations on which this thesis is based upon have contributed to an increased understanding of some of these particles and to the development of a method that could be used to study their structure. LÄS MER

  7. 25. Design and analysis of wireframe DNA nanostructures

    Författare :Erik Benson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the last decades, the powerful self-assembly properties of DNA have been harnessed to produce complex structures at the nanoscale with high precision and yield. DNA origami is one of the most robust examples of this, where a 7000-nucleotide strand of biological origin is folded by hybridizing with hundreds of synthetic oligonucleotides, the programmed sequence of these “staple strands” determines the shape of the assembled object. LÄS MER