Sökning: "virus structure"

Visar resultat 1 - 5 av 174 avhandlingar innehållade orden virus structure.

  1. 1. Exploring the Molecular Dynamics of Proteins and Viruses

    Författare :Daniel Larsson; David van der Spoel; Modesto Orozco; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; molecular dynamics; virus dynamics; capsid dissolution; satellite tobacco necrosis virus; satellite tobacco mosaic virus; virus genome structure; gas phase protein structure; water layer; micelle embedded protein; membrane protein; Chemistry with specialization in Biophysics; Kemi med inriktning mot biofysik;

    Sammanfattning : Knowledge about structure and dynamics of the important biological macromolecules — proteins, nucleic acids, lipids and sugars — helps to understand their function. Atomic-resolution structures of macromolecules are routinely captured with X-ray crystallography and other techniques. LÄS MER

  3. 2. Ljungan Virus Replication in Cell Culture

    Författare :Jens-Ola Ekström; Kjell Edman; Glyn Stanway; Högskolan i Kalmar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ljungan virus; picornavirus; parechovirus; 5 - RACE; 5 -end; infectious cDNA clone; real time PCR; virus purification; virion stability; disinfection; aphthovirus-like 2A; Virology; Virologi; Mikrobiologi; Microbiology;

    Sammanfattning : Ljungan virus (LV) is a recently identified picornavirus of the genus Parechovirus. LV has been isolated from voles trapped in Sweden and also in the United States. LV infected small rodents may suffer from diabetes type 1 and type 2 like symptoms, myocarditis and encephalitis. LÄS MER

  4. 3. Control of Quasi-Equivalence in Virus Capsids

    Författare :Charlotte Helgstrand; B. V. Venkataram Prasad; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; crystallography; bacteriophage; virus; RNA; capsid; quasi-equivalence; assembly; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Many T=3 plant and insect viruses use a molecular switch in form of order/disorder of a segment of the polypeptide chain to regulate the quasi-equivalent contacts. The structure of a mutant of the T=3 capsid of bacteriophage fr confirms that this virus and other members of the Leviviridae family lack a switch mechanism. LÄS MER

  5. 4. The Design and Structure Prediction of Protein Oligomers

    Författare :Robert Lizatovic; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virus capsids; coiled coils; molecular replacement; symmetry; Rosetta; protein design; structure prediction;

    Sammanfattning : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. LÄS MER

  7. 5. Structural Decorations in Viruses : Unraveling Acquired Functional Structures in Icosahedral RNA Virus Capsids

    Författare :Han Wang; Kenta Okamoto; Sarah Butcher; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Viruses; RNA viruses; capsid; structure; cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Viruses have a profound impact worldwide, posing challenges to animal welfare, agriculture, human health, and the ecosystem. This thesis examines the realm of non-enveloped icosahedral double-stranded (ds)RNA and single-stranded (ss)RNA viruses through three studies. LÄS MER