Sökning: "CpG islands"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden CpG islands.
1. Genome-wide epigenetic profiling of B cell leukemia and lymphoma
Sammanfattning : Epigenetic modifications, at the level of DNA methylation and post-translational modifications of histone tails cooperatively function in the organization of the genome, and thereby establish the gene expression profiles, phenotypes, and cellular fates. In this work, we investigated the aberrant epigenome in chronic lymphocytic leukemia (CLL) which is one of the most frequent lymphoid malignancies in the west including the Nordic countries. LÄS MER
2. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution
Sammanfattning : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. LÄS MER
3. Molecular characterization of the hepatitis C virus core protein
Sammanfattning : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. LÄS MER
4. Towards forecasting epigenetic repression
Sammanfattning : Multicellular organisms form many different cell types from one genome, which requires differential gene activity. The Polycomb system upholds the correct gene expression programs by epigenetically silencing genes that encode critical transcription regulators. LÄS MER
5. Bioinformatic identification of disease associated pathways by network based analysis
Sammanfattning : Many common diseases are complex, meaning that they are caused by many interacting genes. This makes them difficult to study; to determine disease mechanisms, disease-associated genes must be analyzed in combination. LÄS MER