Sökning: "CpG island"
Visar resultat 1 - 5 av 23 avhandlingar innehållade orden CpG island.
1. The CpG island methylator phenotype in colorectal cancer : studies on risk and prognosis
Sammanfattning : Background Colorectal cancer (CRC) is the second most common malignancy in developed countries. The mortality is high, with nearly half of patients dying from the disease. The primary treatment of CRC is surgery, and decisions about additional treatment with chemotherapy are based mainly on tumor stage. LÄS MER
2. Biological signature of HER2-positive breast cancer
Sammanfattning : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. LÄS MER
3. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution
Sammanfattning : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. LÄS MER
4. Molecular characterization of the hepatitis C virus core protein
Sammanfattning : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. LÄS MER
5. Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes
Sammanfattning : Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. LÄS MER