Sökning: "Tanel Punga"

Hittade 3 avhandlingar innehållade orden Tanel Punga.

  1. 1. The Interaction of the Adenovirus E1B-55K Protein with a Histone Deacetylase Complex: Its Importance in Regulation of P53 Protein Functions

    Författare :Tanel Punga; Göran Akusjärvi; Klas G. Wiman; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; adenovirus; E1B-55K; p53; histone acetylation; Sin3; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : The human tumour suppressor protein p53 is an effective inhibitor of cell growth, by inducing cell cycle arrest and apoptosis. However, p53-induced cell growth inhibition can be detrimental for virus multiplication. Therefore, viruses encode for proteins, which can interfere with the functions of the p53 protein. LÄS MER

  2. 2. Functional characterization of the human adenovirus pVII protein and non-coding VA RNAI

    Författare :Raviteja Inturi; Tanel Punga; Goran Akusjarvi; Thomas Dobner; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Adenovirus; VA RNA; protein VII; Ubiquitination; proteasome; anti-viral; Medical Biochemistry; Medicinsk biokemi; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

    Sammanfattning : Human adenovirus (HAdV) is a common pathogen causing a broad spectrum of diseases. HAdV encodes the pVII protein, which is involved in nuclear delivery, protection and expression of viral DNA. To suppress the cellular interferon (IFN) and RNA interference (RNAi) systems, HAdVs encode non-coding virus-associated (VA) RNAs. LÄS MER

  3. 3. Human adenovirus – host cell interplay : The role of the cellular zinc finger proteins and mitochondrial DNA

    Författare :Kwangchol Mun; Tanel Punga; Stefan Schwartz; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Adenovirus; Protein VII; Ubiquitination; Chromatin remodeling; Mitochondria;

    Sammanfattning : Human adenovirus (HAdV) is an abundant DNA virus with significant clinical relevance since it cauces a variety of respiratory, ocular, and gastrointestinal diseases. It is also intensively used as a therapeutic tool to treat cancers and to boost immune responses. LÄS MER