Sökning: "SHP-1"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet SHP-1.

  1. 1. Molecular characterization of the hepatitis C virus core protein

    Författare :Priya Devi; Anders Bergqvist; Björn Olsen; Tanel Punga; Gerald McInerney; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; HCV; core protein; SHP-1; CpG methylation; bisulfite sequencing; NGS; PBMC; Ca2 NFAT; strand-specific RT qPCR; Klinisk virologi; Clinical Virology; Infektionssjukdomar; Infectious Diseases; Mikrobiologi; Microbiology; Medical Virology; Medicinsk virologi;

    Sammanfattning : Hepatitis C virus (HCV) is an RNA virus that causes chronic infection, which can lead to hepatocellular carcinomas in humans. Besides liver diseases, the chronic HCV infection causes a broad spectrum of extrahepatic complications such as lymphoproliferative, metabolic and autoimmune disorders. LÄS MER

  3. 2. Expression and function of the protein tyrosine phosphatases SHP-1 and SHP-2 in prostate cancer

    Författare :Helena Tassidis; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer SHP-1SHP-2 IL-6phosphorylationsignalling pathways;

    Sammanfattning : Prostate cancer is one of the most frequent cancers in males in Western countries. Radical prostatectomy serves as the first line of treatment for patients with localised prostate cancer. However, in many cases the cancer will recur. It is currently difficult to identify those patients at a high risk of tumour recurrence. LÄS MER

  4. 3. Novel imaging technology and tools for biomarker detection in cancer

    Författare :Zahra El-Schich; Malmö högskola; []
    Nyckelord :Biomarkers; Kronisk lymfatisk leukemi; Early detection of cancer; Diagnosis; Leukemia; Lymphocytic; Chronic; B-Cell; Apoptosis; Digital holografi;

    Sammanfattning : Cancer is a leading cause of death worldwide. Normally the balance betweencell growth and cell death is strongly controlled. Chronic lymphocytic leukemiais an indolent disease that has a highly variable clinical course and is the mostcommon hematological malignancy amongst adults in the Western countries. LÄS MER

  5. 4. Importance of microenvironment and antigen in the regulation of growth and survival of CLL cells

    Författare :Ann-Charlotte Bergh; Anders Rosén; Richard Rosenquist Brandell; Dimitar Efremov; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) cells rapidly die when put in culture implying that microenvironmental signals delivered by accessory cells confer CLL cells with a growth advantage. Recent findings show that CLL cells are antigen experienced and antigen binding play a critical role in the pathogenesis of the disease. LÄS MER

  7. 5. Prognostic molecular markers of childhood leukemia

    Författare :Fredrika Gauffin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute lymphoblastic leukemia; dic 9; 20 ; dried blood spots; Guthrie card; RNA; PTEN; SHP1; VEGF; VEGFR-1; VEGFR-2; immuhistochemistry; tissue micro array;

    Sammanfattning : During the last decades there has been a dramatic increase in survival rates for childhood leukemia, resulting today in an overall survival close to 90 % for children with acute lymphoblastic leukemia (ALL). This accomplishment is largely due to treatment protocols based on careful risk group assessment guiding the type and intensity of the anti-leukemic treatment. LÄS MER