Sökning: "FOXG1"

Hittade 3 avhandlingar innehållade ordet FOXG1.

  1. 1. Biological signature of HER2-positive breast cancer

    Författare :Breezy Malakkaran Lindqvist; Sten Wingren; Torbjörn Nilsson; Ingrid Hedenfalk; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HER2 breast cancer; SLC25A43; CpG island; DNA methylation; Homeobox genes; FOXO3a; FOXG1; Biomedicin; Biomedicine;

    Sammanfattning : Human epidermal growth factor receptor 2 (HER2) overexpressing breast cancers (HER2+ breast cancer) are associated with an aggressive disease course. This thesis is focused on improving the understanding of the biological signature of HER2+ breast cancer. LÄS MER

  3. 2. Inferring transcriptional regulation on the promoter level and its applications to diseases

    Författare :Morana Vitezic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene regulation is important in maintaining cell identity and in higher organisms is a very complex process with many layers of regulation. Genome-wide transcriptional studies that define gene expression across different cells and tissues give important insights into overall gene regulation of a cell as well as the impact of dysregulation in diseases. LÄS MER

  4. 3. Let's talk about SOX : diverse key players in the transcriptional regulation of neural stem cells

    Författare :Susanne Klum; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The development of the central nervous system relies on neural stem cells. How these stem cells either maintain their identity as self-renewing progenitors or differentiate into cells of the neuronal or glial lineage are fundamental questions. LÄS MER