Sökning: "Boronic Acids"

Visar resultat 6 - 10 av 15 avhandlingar innehållade orden Boronic Acids.

1. 6. Catalytic Regio- and Stereoselective Reactions for the Synthesis of Allylic and Homoallylic Compounds

   Författare :Rauful Alam; Kalman Szabo; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium catalysis; C−H functionalization; boronic acid; allylboration; asymmetric catalysis; allylic; homoallylic; diastereoselective; enantioselective; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis is focused on two main areas of organic synthesis, palladium-catalyzed functionalization of alkenes and allylic alcohols, as well as development of new allylboration reactions.We have developed a palladium-catalyzed selective allylic trifluoroacetoxylation reaction based on C−H functionalization. LÄS MER

3. 7. Synthesis of chiral allyl and propargyl boronates by organocatalytic carbene insertion to carbon-boron bonds

   Författare :Marie Deliaval; Kálmán Szabó; Fahmi Himo; Carlos Valdés; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; boron; asymmetric synthesis; organocatalysis; allylic compounds; allenols; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis describes the development of a novel organocatalytic method for the synthesis of chiral allyl- and propargyl- organoboron compounds with high enantioselectivity. These organoboron species are versatile building blocks in asymmetric synthesis.We have developed a new efficient homologation method of alkenyl boronic acids. LÄS MER

4. 8. Palladium(II)-Catalyzed Oxidative Carbocyclization/Functionalization of Allenynes

   Författare :Teresa Bartholomeyzik; Jan-Erling Bäckvall; Diego J. Cárdenas; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium catalysis; oxidation; carbocyclization; allenynes; boron reagents; kinetics; selectivity; reaction mechanism; organisk kemi; Organic Chemistry;

   Sammanfattning : The selective formation of carbon-carbon bonds constitutes a key transformation in organic synthesis with useful applications in pharmaceutical or material industry. A particularly versatile tool for carbon-carbon as well as carbon-heteroatom bond formation is palladium catalysis, which allows for mild and selective routes even towards complex structures. LÄS MER

5. 9. Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

   Författare :Anneli Nordqvist; Anders Karlén; Mats Larhed; Anders Hallberg; Anna Linusson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; Glutamine synthetase; Imidazo[1; 2-a]pyridine analogues; Focused hierarchical design of experiments; DXR; Fosmidomycin analogues; 1-Deoxy-D-xylulose-5-phosphate reductoisomerase; Cinnamaldehydes; Oxidative Heck reaction; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. LÄS MER

7. 10. Selectivity in Palladium- and Enzyme-Catalyzed Reactions : Focusing on Enhancement of Reactivity

   Författare :Peter Nilsson; Anders Hallberg; Mats Larhed; Matthias Beller; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Palladium; Heck; PCR; Microwaves; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

   Sammanfattning : Catalysis has a profound impact on all living species on the earth. Nature’s catalysts, the enzymes, have the ability to selectively promote a specific bio-chemical transformation, given the required substrate. LÄS MER