Sökning: "Focused hierarchical design of experiments"

Hittade 3 avhandlingar innehållade orden Focused hierarchical design of experiments.

  1. 1. Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

    Författare :Anneli Nordqvist; Anders Karlén; Mats Larhed; Anders Hallberg; Anna Linusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; Glutamine synthetase; Imidazo[1; 2-a]pyridine analogues; Focused hierarchical design of experiments; DXR; Fosmidomycin analogues; 1-Deoxy-D-xylulose-5-phosphate reductoisomerase; Cinnamaldehydes; Oxidative Heck reaction; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. LÄS MER

  3. 2. Cross-functional brain imaging of attention, memory, and executive functions : Unity and diversity of neurocognitive component processes

    Författare :Petter Marklund; Lars Nyberg; Akira Miyake; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Human memory; executive functions; prefrontal cortex; sustained and transient neural activity; declarative long-term memory; attention; working memory; functional neuroimaging; cognitive control.; Psychology; Psykologi;

    Sammanfattning : The central theme of the present thesis revolves around the exploration of similarities and differences in brain activity patterns invoked by the component processes underlying mnemonic, executive and attentional functions. The primary aim was to identify and functionally characterize commonly recruited brain regions in terms of shared component processes, which has been a largely neglected area of research in cognitive neuroscience. LÄS MER

  4. 3. Modeling of Modular Multilevel Converters for Stability Analysis

    Författare :Luca Bessegato; Stefan Östlund; Staffan Norrga; Lennart Harnefors; Xiongfei Wang; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Modular multilevel converters MMCs ; stability; admittance; frequency-domain analysis; linearization techniques; current control; voltage control; ac ac converters; railway engineering.; Modulära multinivåomvandlare MMC ; stabilitet; admittans; frekvensanalys; linjäriseringsmetoder; strömreglering; spänningsreglering; ac ac omvandlare; järnvägsteknik.; Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : Modular multilevel converters (MMCs) have recently become the state-of-the-art solution for various grid-connected applications, such as high-voltage direct current (HVDC) systems and flexible alternating current transmission systems (FACTS). Modularity, scalability, low power losses, and low harmonic distortion are the outstanding properties that make MMCs a key technology for a sustainable future. LÄS MER