Sökning: "C−H functionalization"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden C−H functionalization.

  1. 1. Iridium-Catalyzed C−H Activation Methods for Late-Stage Functionalization of Pharmaceuticals

    Författare :Erik Weis; Belén Martín‐Matute; Jin-Quan Yu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amination; catalysis; C-H activation; C-H functionalization; high-throughput experimentation; iodination; iridium; isotope labelling; late-stage functionalization; methylation; Organic Chemistry; organisk kemi;

    Sammanfattning : C-H activations have over the recent decades risen from a mere curiosity to a viable synthetic strategy. However, challenges in terms of accessible transformations, selectivity and functional group tolerance limit the widespread applicability of this approach. LÄS MER

  3. 2. Catalytic Regio- and Stereoselective Reactions for the Synthesis of Allylic and Homoallylic Compounds

    Författare :Rauful Alam; Kalman Szabo; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium catalysis; C−H functionalization; boronic acid; allylboration; asymmetric catalysis; allylic; homoallylic; diastereoselective; enantioselective; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis is focused on two main areas of organic synthesis, palladium-catalyzed functionalization of alkenes and allylic alcohols, as well as development of new allylboration reactions.We have developed a palladium-catalyzed selective allylic trifluoroacetoxylation reaction based on C−H functionalization. LÄS MER

  4. 3. C–H and Si–H functionalization using redox-active diazo compounds and decarboxylative coupling

    Författare :Rajdip Chowdhury; Abraham Mendoza; Darren Dixon; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbenes; radicals; redox-active esters; indoles; carboxylic acids; silanes; photochemistry; Organic Chemistry; organisk kemi;

    Sammanfattning : The work presented in this thesis is based on two basic organic chemistry concepts: carbene catalysis and radical coupling reactions. Diazo compounds in the presence of transition-metal catalysts are known to be excellent reagents for the construction of C–X bonds (X = C, Si, N, O, etc.) under mild conditions. LÄS MER

  5. 4. Palladium(II)-Catalyzed Oxidative Carbocyclization/Functionalization of Allenynes

    Författare :Teresa Bartholomeyzik; Jan-Erling Bäckvall; Diego J. Cárdenas; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium catalysis; oxidation; carbocyclization; allenynes; boron reagents; kinetics; selectivity; reaction mechanism; organisk kemi; Organic Chemistry;

    Sammanfattning : The selective formation of carbon-carbon bonds constitutes a key transformation in organic synthesis with useful applications in pharmaceutical or material industry. A particularly versatile tool for carbon-carbon as well as carbon-heteroatom bond formation is palladium catalysis, which allows for mild and selective routes even towards complex structures. LÄS MER

  7. 5. New Strategies for Transition Metal-mediated (Hetero)arene Functionalization

    Författare :Fredric Ingner; Lukasz Pilarski; Joanna Wencel-Delord; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis describes new approaches to achieve efficient and selective (hetero)arene derivatization using transition metals. The main focus falls on the use of strategies based on C–H activation and organo-main group reactivity to render the synthesis of various (hetero)arene derivatives more direct, efficient, regioselective and sustainable. LÄS MER