Sökning: "Biomarkers cancer"

Visar resultat 16 - 20 av 436 avhandlingar innehållade orden Biomarkers cancer.

1. 16. Improving the diagnostic armamentarium of lung cancer

   Författare :Hedvig Elfving; Patrick Micke; Fredrik Pontén; Marika Nestor; Reinhard Büttner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung cancer; tissue microarray; immunohistochemistry; targeted therapy; immunotherapy; checkpoint inhibitors; immune microenvironment; prognosis; biomarkers; immune cells.;

   Sammanfattning : Lung cancer is the leading cause of cancer-related death globally, with non-small cell lung cancer (NSCLC) constituting 85% of cases. The introduction of immunotherapies and targeted therapies have dramatically improved the prognosis and outcome for a subset of patients, and stressed the development of diagnostic tools for effective patient selection. LÄS MER

3. 17. Disease and Illness Trajectories of Pancreatic Cancer

   Författare :Sofie Olsson Hau; Terapeutisk patologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; quality of life; Gender; Biomarkers;

   Sammanfattning : .... LÄS MER

4. 18. RNA Sequencing for Molecular Diagnostics in Breast Cancer

   Författare :Christian Brueffer; Translational Oncogenomics; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer; Breast Cancer; RNA sequencing; Gene Expression; Mutation; Biomarker; SCAN-B; Diagnostics; Precision Medicine;

   Sammanfattning : Breast cancer is the most common type of cancer in women and, in Sweden, is the most deadly second only to lung cancer. While treatment and diagnostic options have improved in the past decades and short- to mid-term survival is good, long-term survival is much poorer. LÄS MER

5. 19. Colorectal Cancer : Aspects of Heredity, Prognosis and Tumour Markers

   Författare :Lana Ghanipour; Helgi Birgisson; Lars Påhlman; Karin Jirström; Tom Öresland; Uppsala universitet; []
   Nyckelord :colorectal cancer; heredity; Tryptophanyl t-RNA synthetase; microsatellite instability; SP-PLA; prognosis; biomarkers;

   Sammanfattning : Colorectal cancer (CRC) is one of the most common cancer types and leading causes of cancer death worldwide. Since CRC is a heterogenic disease, there is a demand for increased knowledge of the underlying genetic and epigenetic mechanisms. The aim of this thesis was to investigate heredity and potential tumour markers in relation to prognosis. LÄS MER

7. 20. Towards Personalized Cancer Therapy : New Diagnostic Biomarkers and Radiosensitization Strategies

   Författare :Diana Spiegelberg; Marika Nestor; Bo Stenerlöw; Johan Lennartson; Theodosia Maina-Nock; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor targeting; radionuclide targeting; HSP90 inhibition; AT13387; radiosensitization; molecular imaging; combination treatment; EGFR; CD44v6; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : This thesis focuses on the evaluation of biomarkers for radio-immunodiagnostics and radio-immunotherapy and on radiosensitization strategies after HSP90 inhibition, as a step towards more personalized cancer medicine. There is a need to develop new tracers that target cancer-specific biomarkers to improve diagnostic imaging, as well as to combine treatment strategies to potentiate synergistic effects. LÄS MER