Sökning: "checkpoint inhibitors"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden checkpoint inhibitors.

  1. 1. Improving the diagnostic armamentarium of lung cancer

    Författare :Hedvig Elfving; Patrick Micke; Fredrik Pontén; Marika Nestor; Reinhard Büttner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung cancer; tissue microarray; immunohistochemistry; targeted therapy; immunotherapy; checkpoint inhibitors; immune microenvironment; prognosis; biomarkers; immune cells.;

    Sammanfattning : Lung cancer is the leading cause of cancer-related death globally, with non-small cell lung cancer (NSCLC) constituting 85% of cases. The introduction of immunotherapies and targeted therapies have dramatically improved the prognosis and outcome for a subset of patients, and stressed the development of diagnostic tools for effective patient selection. LÄS MER

  3. 2. Checkpoint inhibitor-induced adverse events in the CNS - T-cell characteristics and biomarkers

    Författare :Sara Bjursten; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Immune checkpoint inhibition; Immune related adverse events to the CNS; T cells;

    Sammanfattning : Immune checkpoint inhibitors (ICI) activate T cells to kill cancer cells by blocking inhibitory receptors PD-1 (nivolumab; nivo) or CTLA-4 (ipilimumab; ipi). Activated T cells can also attack any healthy organ, causing unpredictable immune related adverse events (irAE). The risk of irAE is highest when treating with ipi and nivo simultaneously. LÄS MER

  4. 3. Redox reactions in cancer: impact and regulation

    Författare :Hanna Grauers Wiktorin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Immunotherapy; reactive oxygen species; NOX2; histamine dihydrochloride; myeloid-derived suppressor cells; checkpoint inhibition; acute myeloid leukemia; chronic myeloid leukemia;

    Sammanfattning : The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of myeloid cells, NOX2, is a major source of oxidants in the form of reactive oxygen species (ROS), which are short-lived oxygen derivatives. LÄS MER

  5. 4. LOAd703 and beyond : Advancing immunostimulatory gene therapy for cancer

    Författare :Jessica Wenthe; Angelica S. Loskog; Marco Donia; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Immunotherapy; Gene therapy; Oncolytic virus; Adenovirus; CAR T cells; Immune checkpoint inhibition; CD40L; 4-1BBL; IL-2;

    Sammanfattning : In the last decade, immunotherapy has come into the limelight of cancer treatments. Immunotherapy aims to stimulate the body’s own immune system to create or reinvigorate anti-tumor immune responses. LÄS MER

  7. 5. Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma

    Författare :Maria Wolodarski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also changed the way we treat malignancies in general and the treatment of melanoma has been the role model for new treatment strategies. LÄS MER