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Visar resultat 16 - 18 av 18 avhandlingar som matchar ovanstående sökkriterier.

1. 16. Ultrasound-assisted Interactions of Natural Killer Cells with Cancer Cells and Solid Tumors

   Författare :Athanasia Christakou; Martin Wiklund; Sabeth Verpoorte; KTH; []
   Nyckelord :Natural killer cell; cytotoxicity; heterogeneity; multiwell microchip; biocompatibility; ultrasonic cell manipulation; 3D cell culture; solid tumor; spheroid; high-resolution imaging; Biologisk fysik; Biological Physics;

   Sammanfattning : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. LÄS MER

3. 17. Characterisation of inputs and outputs of striatal medium spiny neurons in health and disease

   Författare :Marko Filipović; Jeanette Hellgren Kotaleski; Arvind Kumar; Gilad Silberberg; Ad Aertsen; Andrew Sharott; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; basal ganglia; striatum; medium spiny neurons; subthalamic nucleus; globus pallidus; Parkinson s disease; in vivo; oscillations; spectral analysis; response variability; networks; simulations; modelling; Numerical Analysis; Numerisk analys; Computer Science; Datalogi; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

   Sammanfattning : Striatal medium spiny neurons (MSNs) play a crucial role in various motor and cognitive functions. They are separated into those belonging to the direct pathway (dMSNs) and the indirect pathway (iMSNs) of the basal ganglia, depending on whether they express D1 or D2 type dopamine receptors, respectively. LÄS MER

4. 18. Investigation of Neuronal Protein Trafficking at the Molecular Scale

   Författare :Martina Damenti; Ilaria Testa; Clive Bramham; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Endoplasmic Reticulum; Mitochondria; Arc Activity-regulated cytoskeleton-associated protein ; oligomerization; pRESOLFT; STED; event-triggered FCS; DNA-PAINT; STARSS; molecular dynamics simulations; Biological and Biomedical Physics; Biologisk och biomedicinsk fysik;

   Sammanfattning : Neurons are polarized cells that encode information in the nervous system viaelectrochemical connections named synapses. The tuning of synapticconnections is enabled by a plastic protein trafficking system which operates atthe nanoscale to finely tweak the neuronal ultrastructure. LÄS MER