Sökning: "spheroid"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet spheroid.

  1. 1. Ultrasound-assisted Interactions of Natural Killer Cells with Cancer Cells and Solid Tumors

    Författare :Athanasia Christakou; Martin Wiklund; Sabeth Verpoorte; KTH; []
    Nyckelord :Natural killer cell; cytotoxicity; heterogeneity; multiwell microchip; biocompatibility; ultrasonic cell manipulation; 3D cell culture; solid tumor; spheroid; high-resolution imaging; Biologisk fysik; Biological Physics;

    Sammanfattning : In this Thesis, we have developed a microtechnology-based method for culturing and visualizing high numbers of individual cells and cell-cell interactions over extended periods of time. The foundation of the device is a silicon-glass multiwell microplate (also referred as microchip) directly compatible with fluorescence microscopy. LÄS MER

  2. 2. Ultrasonic Fluid and Cell Manipulation

    Författare :Mathias Ohlin; Martin Viklund; Hans Hertz; Peter Glynne-Jones; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; 3D cell culture; Acoustic streaming; Acoustofluidics; Cell manipulation; High-resolution imaging; Multi-well; Microplate; Natural killer cell; Piezo; Radiation force; Solid tumor; Solubilization; Spheroid; Standing wave; Temperature control; Transducer; Trapping; Ultrasonic; Physics; Fysik; Biologisk fysik; Biological Physics;

    Sammanfattning : During the last decade, ultrasonic manipulation has matured into an important tool with a wide range of applications, from fundamental cell biological research to clinical and industrial implementations. The contactless nature of ultrasound makes it possible to manipulate living cells in a gentle way, e.g. LÄS MER

  3. 3. Multicellular Tumour Spheroids in a Translational PET Imaging Strategy

    Författare :Azita Monazzam; Mats Bergström; Carl Blomqvist; Jörgen Carlsson; Raymond Josephsson; Eric O Aboagye; Uppsala universitet; []
    Nyckelord :Oncology; Positron Emission Tomography; Multicellular Tumour Spheroid; Translational Research; Onkologi;

    Sammanfattning : Positron Emission Tomography (PET) has gained an important roll in clinical for diagnosis, staging and prognosis of a range of cancer types. Utilization of PET for monitoring and evaluation of cancer treatment is an attractive but almost new concept. The proper choice of PET-tracer as a biomarker for treatment follow-up is crucial. LÄS MER

  4. 4. Hepatic 3D spheroids as a model system for drug-induced liver injury and cytochrome P450 induction

    Författare :Delilah F. G. Hendriks; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Drug-induced liver injury (DILI) is a major cause of post-marketing drug withdrawals and restricted-use warnings. In addition, unexpected adverse hepatic drug reactions occurring in the clinical phases of development are a major reason for drug attrition. LÄS MER

  5. 5. Using a 3-d model system to screen for drugs effective on solid tumors

    Författare :Walid Fayad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : There is a large medical need for the development of effective anticancer agents with minimal side effects. The present thesis represents an attempt to identify potent drugs for treatment of solid tumors. LÄS MER