Sökning: "ApoE"

Visar resultat 1 - 5 av 145 avhandlingar innehållade ordet ApoE.

  1. 1. Odor identification in aging and dementia : Influences of cognition and the ApoE gene

    Författare :Jonas Olofsson; Steven Nordin; Maria Larsson; Richard Doty; Umeå universitet; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; Aging; olfaction; identification; dementia; Alzheimer; genetics; ApoE; population based; cognition; demographics; Psychology; Psykologi;

    Sammanfattning : Olfactory function is impaired in aging and dementia. The general aim of this thesis was to identify variables that predict olfactory function and dysfunction (assessed with an odor identification test) in middle-aged and elderly adults. LÄS MER

  2. 2. Biomarkers for Alzheimer's disease and the APOE polymorphism

    Författare :Ronald Lautner; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Biomarkers; APOE; Cerebrospinal fluid; β-amyloid;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarkers reflecting the core pathology of AD are now widely used for diagnosis making, in particular β-amyloid[1-42] (Aβ42) reflecting amyloid plaque pathology, phosphorylated tau (P-tau) reflecting neurofibrillary tangle pathology and total tau (T-tau) reflecting general neurodegeneration. In addition, blood-based biomarkers for AD are in the pipeline with recent studies showing promising diagnostic potential. LÄS MER

  3. 3. Cognitive change in aging: A life span perspective of gender and individual differences in APOE genotype

    Författare :Marcus Praetorius; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :cognitive performance; late life; APOE; gender; time to death;

    Sammanfattning : Degree of licentiate in Psychology Abstract Praetorius, M. (2011). Cognitive change in aging: A life span p erspective of gender and individual differences in APOE genotype. LÄS MER

  4. 4. Genes to remember : imaging genetics of hippocampus-based memory functions

    Författare :Karolina Kauppi; Lars Nyberg; Jonas Persson; Guillén Fernández; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Imaging genetics; fMRI; Episodic memory; SNP; KIBRA; BDNF; APOE; Hippocampus; Parahippocampus;

    Sammanfattning : In the field of imaging genetics, brain function and structure are used as intermediate phenotypes between genes and cognition/diseases to validate and extend findings from behavioral genetics. In this thesis, three of the strongest candidate genes for episodic memory, KIBRA, BDNF, and APOE, were examined in relation to memory performance and hippocampal/parahippocampal fMRI blood-oxygen level-dependent (BOLD) signal. LÄS MER

  5. 5. Olfactory Function : The Influence of Demographic, Cognitive, and Genetic Factors

    Författare :Margareta Hedner; Maria Larsson; Lars-Göran Nilsson; Claire Murphy; Stockholms universitet; []
    Nyckelord :SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Olfaction; odor identification; odor threshold; odor discrimination; aging; gender; ApoE; BDNF; val66met; association study; population-based; psykologi; Psychology;

    Sammanfattning : Olfactory function is affected by demographic, cognitive, and genetic factors. In the present thesis, three empirical studies investigated individual differences in olfactory ability. Study I explored demographic and cognitive correlates in common olfactory tasks; odor detection, odor discrimination, and odor identification. LÄS MER