Sökning: "B-ALL"

Visar resultat 11 - 15 av 21 avhandlingar innehållade ordet B-ALL.

  1. 11. Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia

    Författare :Edward Laane; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :acute leukemia; glucocorticoids; doxorubicin; apoptosis; autophagy; minimal residual disease; dendritic cells;

    Sammanfattning : Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult myeloid AL (AML). LÄS MER

  3. 12. Prognostic factors, treatment and outcome in adult acute lymphoblastic leukemia : Population-based studies in Sweden

    Författare :Piotr Kozlowski; Helene Hallböök; Maria Åström; Anita W. Rijneveld; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute Lymphoblastic Leukemia; adult; chemotherapy; prognosis; population-based; Onkologi; Oncology;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) has poor prognosis in older/elderly adults and in high-risk/relapsed disease. Recommended treatment of ALL was evaluated (study I-IV). Data was obtained from the Swedish Acute Leukemia registries and from patient records.I. LÄS MER

  4. 13. The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer

    Författare :Shahab Akhoondi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various human tumor types and explored alternative mechanism(s) for the inactivation of FBW7. LÄS MER

  5. 14. MiRNAs in cancer

    Författare :Masako Harada; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There are many layers of complexity involving the processes through which somatic cells transform into malignant cancers. Historically, cancer was considered to be a disease primarily caused by gene mutations, however it is now well established that the dysregulated expression of the genes leading to the tumorigenic phenotype involves not only mutations but also epigenetic changes. LÄS MER

  7. 15. The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing

    Författare :Henrik Zetterquist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Clinical transplantation; HLA; histocompatibility testing; PCR; allele-specific amplification; sequence-specific primers; bone marrow transplantation; mixed chimerism; minimal residual disease; acute lymphoblastic leukemia;

    Sammanfattning : Transplantation immunology basically deals with the immune mechanisms that lead to rejection of transplanted tissues. Lymphocytes are the key mediators of graft rejection. At the time for this observation, the genetic loci responsible for histocompatibility between individuals of the same species were already identified in the mouse. LÄS MER