Sökning: "Shahab Akhoondi"

Hittade 1 avhandling innehållade orden Shahab Akhoondi.

1. 1. The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer

   Författare :Shahab Akhoondi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various human tumor types and explored alternative mechanism(s) for the inactivation of FBW7. LÄS MER