Sökning: "Anders Olofsson"

Visar resultat 16 - 20 av 33 avhandlingar innehållade orden Anders Olofsson.

  1. 16. Accumulation and Cellular Clearance of IAPP and Proteotoxicity of ATTR in Drosophila Models

    Författare :Xiaohong Gu; Gunilla Westermark; Anders Olofsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; ATTR; ATTR amyloidosis; crystalline structure; aggrephagy; Drosophila melanogaster; Gal4-UAS; electron tomography; DAMS; SOHA; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Proteins’ functions are dependent on their three-dimensional (3D) structure. Under certain circumstances, proteins misfold and form aggregates, sometimes leading to amyloidosis. Islet amyloid polypeptide (IAPP) builds up amyloid in the pancreatic islet of patients with type 2 diabetes (T2D). LÄS MER

  3. 17. Conditions for Technology Enhanced Learning and Educational Change : a case study of a 1:1 initiative

    Författare :Marcia Håkansson Lindqvist; Anders D. Olofsson; Limin Gu; Trond-Eiliv Hauge; Rosemary Luckin; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; digital technologies; ICT; laptops; one-to-one; school development; school leaders; students; teachers; teacher professional development; TEL;

    Sammanfattning : The uptake and use of digital technologies continues to increase in schools throughout the world. In many schools the uptake and use of digital technologies takes place in One-to-One (1:1) initiatives in which teachers and students have their own laptops. LÄS MER

  4. 18. Selection of transthyretin amyloid inhibitors

    Författare :Irina Iakovleva; Anders Olofsson; Göran Larsson; Bente Westergaard; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transthyretin; TTR; ATTR; TTR-stabilizing drugs; selectivity; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Amyloidosis is a group of clinical disorders caused by the aggregation of specific proteins into abnormal extracellular deposits. Today, 31 different proteins have been linked to amyloid diseases including transthyretin-related amyloidosis (ATTR). LÄS MER

  5. 19. Mechanistic and morphological studies of Aβ amyloid formation using surface plasmon resonance

    Författare :Md Tohidul Islam; Anders Olofsson; Ludmilla Morozova-Roche; Vytautas Smirnovas; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; medicinal chemistry; läkemedelskemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia and apart from the individual suffering AD also causes a large economic burden for society. AD is associated with progressive neurodegeneration and atrophy of the brain. LÄS MER

  7. 20. Propagation of singularities for pseudo-differential operators and generalized Schrödinger propagators

    Författare :Karoline Johansson; Joachim Toft; Anders Olofsson; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Banach spaces; Fourier; Generalized time-dependent Schrödinger equation; Micro-local; Modulation spaces; Non-tangential convergence; Pseudo-differential operators; Regularity; Wave-front sets; Banachrum; Fourier; Generaliserad tidsberoende Schrödinger ekvation; Icke-tangentiell konvergens; Mikrolokal; Modulationsrum; Pseudodifferentialoperatorer; Regularitet; Vågfrontsmängder; Mathematical analysis; Analys; Mathematics; Matematik;

    Sammanfattning : In this thesis we discuss different types of regularity for distributions which appear in the theory of pseudo-differential operators and partial differential equations. Partial differential equations often appear in science and technology. LÄS MER