Sökning: "EXT1"

Hittade 4 avhandlingar innehållade ordet EXT1.

  1. 1. N-Sulfation and Polymerization in Heparan Sulfate Biosynthesis

    Författare :Jenny Presto; Lena Kjellén; Gunnar Pejler; Anders Malmström; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; Heparan sulfate; N-deacetylase N-sulfotransferase; NDST; EXT1; EXT2; Biosynthesis; Cell- och molekylärbiologi;

    Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan present in all cell types covalently attached to core proteins forming proteoglycans. HS interacts with different proteins and thereby affects a variety of processes. LÄS MER

  3. 2. Enzymes involved in heparan sulfate chain elongation : Function of a novel family of tumor suppressors?

    Författare :Thomas Lind; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; heparan sulfate; biosynthesis; glycosyltransferase; EXT1; EXT2; UDP-glucosedehydrogenase; KfiC; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Sammanfattning : Heparan sulfate (HS) is a glycosaminoglycan associated with many physiological functions such as regulation of growth factor action and cell adhesion. The HS polysaccharide is synthesized by alternating addition of D-glucuronic acid (GlcA) and N-acetyl-D-glucosamine (GlcNAc) units from the corresponding UDP-sugar precursors. LÄS MER

  4. 3. EXT Proteins in Heparan Sulfate Biosynthesis

    Författare :Marta Busse; Marion Kusche-Gullberg; Tarja Kinnunen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Molekylärbiologi; Molecular biology; Molekylärbiologi;

    Sammanfattning : Heparan sulfate (HS) is a long unbranched polysaccharide composed of alternating glucosamine and hexuronic (glucuronic or iduronic) acid residues. Modification by sulfate groups in various positions generates a highly heterogeneous molecule. LÄS MER

  5. 4. Array based genetic profiling of bone and soft tissue tumors

    Författare :Karolin Hansén Nord; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In this thesis, genetic alterations in bone and soft tissue tumors have been investigated with the purpose of identifying regions of importance for tumor development, diagnosis and prognosis. This has primarily been performed by array comparative genomic hybridization analysis and gene expression profiling of cytogenetically analyzed tumors. LÄS MER