Sökning: "ATRA"

Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet ATRA.

1. 1. The Role of Stat1 in Retinoic Acid-induced Myelomonocytic Differentiation of Human Leukemia Cells

   Författare :Anna Dimberg; Ivo Touw; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Stat1; ATRA; U-937; myeloid; differentiation; cell cycle; growth arrest; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : All-trans retinoic acid (ATRA), a biologically active metabolite of vitamin A, is a powerful inducer of terminal differentiation and growth arrest of several myeloid cell lines in vitro. Although the efficacy of ATRA as an anti-cancer drug has been demonstrated by the successful treatment of acute promyelocytic leukemia (APL), knowledge concerning the molecular mechanisms directing ATRA-induced differentiation and cell cycle arrest of myeloid cells is lacking. LÄS MER

3. 2. Signal Transduction in Malignant Cells – Transformation, Activation and Differentiation

   Författare :Karin Kårehed; Fredrik Öberg; Jan-Ingvar Jönsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; transformation; PDGF; PI3K; Rho-GTPase; U-937; FcγRI; macrophage; Stat1; PKR; NFκB; ATRA; differentiation; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Pathology; Patologi;

   Sammanfattning : All aspects of cell life are regulated by signal transduction mechanisms. This thesis describes the regulatory roles of a few key signal transduction molecules involved in three major biological responses. LÄS MER

4. 3. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors

   Författare :Marina Tshuikina Wiklander; Fredrik Öberg; Kenneth Nilsson; Ugo Testa; Uppsala universitet; []
   Nyckelord :Medical sciences; IRF family; ICSBP IRF8; epigenetics; ATRA; TNFα; histone modifications; methylation; transcription; MEDICIN OCH VÅRD;

   Sammanfattning : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. LÄS MER

5. 4. Photoredox Catalysis Driven by Visible Light and Iron N-Heterocyclic Carbene Complexes

   Författare :Lisa de Groot; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; photoredox catalysis; iron N-heterocyclic carbene complexes; Fe-NHC; Visible light; ATRA; BHAS;

   Sammanfattning : Photoredox catalysis is a rapidly expanding field, in which organic transformations are catalysed using light. The most commonly used photoredox catalysts (PCs) are transition metal complexes which absorb in the visible region of the electromagnetic spectrum. LÄS MER

7. 5. Waterfowl herbivory on submerged macrophytes in eutrophic lakes

   Författare :Håkan Sandsten; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; limnology; Marinbiologi; limnologi; Hydrobiology; Växtekologi; Plant ecology; akvatisk ekologi; Djurekologi; Animal ecology; Anas; Fulica atra; Cygnus; alternative stable states; water depth; distribution; plant species composition; hydrophytes; propagule size; Herbivory; tuber; Potamogeton; marine biology; aquatic ecology;

   Sammanfattning : Submerged macrophytes are thought to stabilize clear-water states of shallow lakes. The aim of this thesis was to elucidate how waterfowl herbivory can affect abundance, distribution and species composition of submerged macrophytes in eutrophic lakes. LÄS MER