Sökning: "IRF family"
Hittade 3 avhandlingar innehållade orden IRF family.
1. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors
Sammanfattning : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. LÄS MER
2. Crimean-Congo hemorrhagic fever virus : interferon-induced antiviral mechanisms and immune evasion strategies
Sammanfattning : The Bunyaviridae family is the largest virus family consisting of more than 350 viruses. Despite the increasing knowledge regarding the biology of members of this family, little is known about Crimean-Congo hemorrhagic fever virus (CCHFV), a virus classified within the Nairovirus genus and the causative agent of a severe hemorrhagic fever in humans with high mortality. LÄS MER
3. The role of interferon-regulated genes in the immune system
Sammanfattning : Type I interferons (IFNs) are potent inducers of the first-line defense against pathogens. Their activity leads to the up- and downregulation of a large number of genes with various effects on the immune system, including direct effects on the pathogens. LÄS MER