Sökning: "TNFα"

Visar resultat 1 - 5 av 62 avhandlingar innehållade ordet TNFα.

  1. 1. Modelling of drug-effect on time-varying biomarkers

    Författare :Felix Held; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cortisol; TNFα; hierarchical modelling; turnover model; pharmacokinetic pharmacodynamic modelling; cortisol TNFα hierarchical modelling turnover model pharmacokinetic pharmacodynamic modelling;

    Sammanfattning : Model-based quantification of drug effect is an efficient tool during pre-clinical and clinical phases of drug trials. Mathematical modelling can lead to improved understanding of the underlying biological mechanisms, help in finding shortcomings of experimental design and suggest improvements, or be an effective tool in simulation-based analyses. LÄS MER

  3. 2. Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors

    Författare :Marina Tshuikina Wiklander; Fredrik Öberg; Kenneth Nilsson; Ugo Testa; Uppsala universitet; []
    Nyckelord :Medical sciences; IRF family; ICSBP IRF8; epigenetics; ATRA; TNFα; histone modifications; methylation; transcription; MEDICIN OCH VÅRD;

    Sammanfattning : Epigenetic modifications were shown to play an essential role in tumorigenesis. Epigenetic mechanisms can alter transcription in several ways, through DNA methylation and/or through histone modification. DNA methylation at the TSS (transcriptional start site) has been implicated in tumor development and gene silencing. LÄS MER

  4. 3. Transcriptional patterns in inflammatory disease

    Författare :Johan Lindberg; Joakim Lundeberg; Eivind Hovig; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Gene expression profiling; transcription; microarray; rheumatoid arthritis; synovial tissue; variability; TNF‐α; anti‐TNF treatment; periodontitis; PGE2; Bioengineering; Bioteknik;

    Sammanfattning : In the studies this thesis is based upon, microarrays were applied to profilemRNA populations in biological samples to gain insights into transcriptionalpatterns and their relation to inflammatory disease.Rheumatoid arthritis (RA) is a chronic inflammatory disease, which leads todegradation of cartilage and bone. LÄS MER

  5. 4. Smac and Smac mimetics in breast cancer cell death

    Författare :Christian Holmgren; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell death; breast cancer; apoptosis; Smac mimetics; Smac; protein kinase C; TRAIL; IAP; TNFα;

    Sammanfattning : .... LÄS MER

  7. 5. Interleukin 1, tumor necrosis factor α and interleukin 6 in the rat central nervous system : production and effects with particular attention to the fever response

    Författare :Silvia Gatti; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurotoxikologi; Tumörer; Onkologi;

    Sammanfattning : .... LÄS MER