Sökning: "transport culture"

Visar resultat 6 - 10 av 81 avhandlingar innehållade orden transport culture.

  1. 6. Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System

    Författare :Björn Jansson; Erik Björk; Sveinbjörn Gizurarson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Administration; intranasal; Nasal mucosa; Central nervous system; Olfactory bulb; Rat; Mouse; Swine; Cattle; Diffusion chambers; culture; In vitro; Biological models; Biological transport; Dextrans; Dopamine; Gels; Polysaccharides; Autoradiography; Fluorescence microscopy; Biofarmaci; Biopharmacy; Biofarmaci;

    Sammanfattning : The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer. LÄS MER

  3. 7. Diagnosing Sharing Anxiety

    Författare :Sigma Dolins; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; ridehailing; sharing anxiety; shared autonomous vehicles; ridepooling; on-demand transport; qualitative methods; shared autonomous public transport; autonomous vehicles; public transport;

    Sammanfattning : Numerous studies indicate that the potential of autonomous vehicles (AVs) to reduce greenhouse gas emissions, reduce traffic congestion, and increase mobility access can only be fully realized through fleets of vehicles being used for shared rides, also known as dynamic ridepooling. This has the potential for transforming the public transport industry, as well as how transportation functions in urban and rural contexts. LÄS MER

  4. 8. Same, Same but Different: On the Design of Cross-Regional Advisory Traffic Information Systems

    Författare :Minjuan Wang; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; traffic safety culture; driving behavior; visual auditory; advisory traffic information system; cross-regional adaptation design; user interface design; information requirements;

    Sammanfattning : As the automotive markets increase rapidly in developing countries, the study of cross-regional differences is certainly becoming an important consideration for in-vehicle technology design. Particularly, when moving from immediate/operational responses to warnings towards tactical responses to advisory information, culture in the form of traffic safety culture (TSC) comes into play in relation to both the information needs and drive behaviours. LÄS MER

  5. 9. Ion transport in exocrine glands with reference to cystic fibrosis

    Författare :Ailing Zhang; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; ion transport; cystic fibrosis; submandibular gland; airway submucosal gland; X-ray microanalysis; cytosolic Ca2 concentration; immunocytochemistry; Cellbiologi; Cell biology; Cellbiologi; Human Anatomy; anatomi;

    Sammanfattning : Aspects of ion transport in rat submandibular gland acinar cells at the subcellular level, and the regulation of chloride secretion and calcium mobilization in cultured pig tracheal gland acinar cells were studied with reference to the disease cystic fibrosis.In adult rat submandibular gland acinar cells, both cholinergic and α-adrenergic stimulation induced efflux of K+ and of C1-, but the response was generally less with α-adrenergic stimulation. LÄS MER

  7. 10. Proteomics informed investigation of human hepatocytes and liver tissue

    Författare :Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. LÄS MER