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Visar resultat 1 - 5 av 39 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Priming and activation of neutrophils from blood and tissue

    Författare :Lisa Davidsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophil; priming; gout; inflammation; transmigration; neutrophil extracellular traps NETs ;

    Sammanfattning : Inflammation is a powerful process, involved in many disease states, as well as in physiological situations. Neutrophils, the main characters of this thesis, are potent immune cells with the capacity to regulate inflammatory responses. In health, circulating blood neutrophils are regarded as quiescent, with limited responsiveness to stimuli. LÄS MER

  2. 2. Cell death and clearance - studies of human neutrophils from blood and tissue

    Författare :Karin Christenson; Göteborgs universitet; []
    Nyckelord :neutrophils; apoptosis; transmigration; phagocytes;

    Sammanfattning : Neutrophils are phagocytic cells that typically migrate from circulation to tissues in order to combat microbial invasion. The journey from blood to tissue involves mobilization of intracellular organelles which results in modifications of surface markers (e.g. LÄS MER

  3. 3. Interleukin-6 Signaling Pathways in Human Vascular Endothelial Cells : Molecular Mechanisms and Associations to Atherosclerosis

    Författare :Mulugeta Melkie Zegeye; Liza Ljungberg; Allan Sirsjö; Ashok K Kumawat; Magnus Grenegård; Stefan Rose-John; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HUVECs; Angiogenesis; Laminins; Transmigration; Biomarker; Cytokine; Inflammation; Myocardial infarction;

    Sammanfattning : Interleukin-6 is pleotropic cytokine produced by several types of cells including endothelial cells (ECs). IL-6 acts on target cells via two major signaling mechanisms known as classic signaling and trans-signaling. LÄS MER

  4. 4. Transmigration of Toxoplasma gondii across biological barriers

    Författare :Emily C. Ross; Antonio Barragan; Ildiko Rita Dunay; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Apicomplexa; blood-brain barrier; leukocyte; immune cell; transendothelial migration; cell adhesion molecule; host-pathogen; FAK; integrin; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Toxoplasma gondii is an obligate intracellular parasite that can likely infect all warm-blooded vertebrates, with estimates of up to 30% of the global human population being infected. Although infection with T. gondii is usually asymptomatic or mild, in immunocompromised individuals infection can lead to lethal toxoplasmic encephalitis. LÄS MER

  5. 5. Regulation of human eosinophil transmigration across lung epithelium

    Författare :Lixin Liu; Uppsala universitet; []
    Nyckelord :Medical sciences; Eosinophils; regulation; migration; epithelial cells; lung; calcium; CD11b CD18; neutrophils; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Chemistry; klinisk kemi;

    Sammanfattning : Eosinophil infiltration into the lung tissues and airways is a hallmark of allergic asthma. To reach the lung lumen, eosinophils migrate across the vascular endothelium, through the interstitial matrix and across lung epithelium. LÄS MER