Sökning: "HUVECs"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet HUVECs.

  1. 1. Epigenetic regulation of gene expression in the vascular endothelium

    Författare :Mia Magnusson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; histone acetylation; DNA methylation; t-PA; PLAT; HUVECs; valproic acid; gene expression; enhancers;

    Sammanfattning : Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to be quite dynamic, DNA methylation has been considered a more stable, or long-term, modification. LÄS MER

  3. 2. Interleukin-6 Signaling Pathways in Human Vascular Endothelial Cells : Molecular Mechanisms and Associations to Atherosclerosis

    Författare :Mulugeta Melkie Zegeye; Liza Ljungberg; Allan Sirsjö; Ashok K Kumawat; Magnus Grenegård; Stefan Rose-John; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HUVECs; Angiogenesis; Laminins; Transmigration; Biomarker; Cytokine; Inflammation; Myocardial infarction;

    Sammanfattning : Interleukin-6 is pleotropic cytokine produced by several types of cells including endothelial cells (ECs). IL-6 acts on target cells via two major signaling mechanisms known as classic signaling and trans-signaling. LÄS MER

  4. 3. Leukotrienes and leukotriene receptors : potential roles in cardiovascular diseases

    Författare :Hong Qiu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukotrienes (LTs) are a family of lipid mediators that are involved in host defense and inflammatory responses. They are synthesized from arachidonic acid through the 5-lipoxygenase (5-LO) pathway, and are divided into two classes, the classical chemoattractant leukotriene B4 (LTB4), and spasmogenic cysteinyl leukotrienes (cys-Us) including LTC4, LTD4 and LTE4. LÄS MER

  5. 4. Lipids and autoimmunity in atherosclerosis and cardiovascular diseases

    Författare :Xiang Hua; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis is an inflammatory disease. The rupture of athrerosclerotic plaques is the major cause of severe cardiovascular disease (CVD), such as myocardial infarction (MI) and stroke. The stability of the plaque depends on its cellular and extracellular contents. LÄS MER

  7. 5. Shock wave effects on the vascular endothelium

    Författare :Anders Sondén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Shock waves; cavitation; explosions; high-energy missile trauma; ESWL; laser; endothelial cells; cell membrane damage; cytoskeleton; adhesion molecules; reactive oxygen species;

    Sammanfattning : A shock wave is a pressure wave with high amplitude and a velocity above sound. Man is exposed to shock waves (SWs) in connection with trauma, e.g. explosions and high-energy missiles and medical treatments such as extracorporeal lithotripsy (ESWL). LÄS MER