Sökning: "thalidomide"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet thalidomide.

  1. 1. Pharmacokinetics of the enantiomers of thalidomide

    Författare :Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER

  3. 2. Experimental modulation and suppression of anti-allograft immune response

    Författare :Öyvind Östraat; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; linomide; leflunomide; cyclophosphamide; mycophenolate mofetil; azathioprine; thalidomide; cyclosporin A; ciprofloxacin; flow cytometry; production; IL-2; Rat cardiac transplantation; allograft; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : Abstract The objective of this investigation was to characterise the immunomodulatory or immunosuppressive effects of single drug treatment and the potential synergistic or additive effects of combined treatment with the focus on ciprofloxacin, thalidomide, mycophenolate mofetil, azathioprine, cyclophosphamide or leflunomide added to cyclosporin A (CyA). A rat cardiac transplant model was used to study graft survival and the influence on lymphocytes was evaluated by in vitro tests. LÄS MER

  4. 3. Studies of anemia in the myelodysplastic syndromes

    Författare :Martin Jädersten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myelodysplasia; growth factors; Cox regression; delayed entry; left truncation; mortality; international prognostic scoring system; IPSS; who-classification based prognostic scoring system; WPSS; thalidomide analogue; IMiD; hematopoietic stem cell; adhesion; stroma; matrix; osteonectin; matricellular protein; NPM1; immunohistochemistry.;

    Sammanfattning : Background: The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders, characterized by chronic anemia and increased risk of transformation to acute myeloid leukemia (AML). The first line therapy of anemia in MDS is erythropoietin (EPO) with or without granulocyte colony-stimulating factor (G-CSF). LÄS MER

  5. 4. "Dom säger att jag ser mer normal ut med benproteser" : om samhällskrav kontra barns behov

    Författare :Karin Paulsson; Stockholms universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Barn Habilitering Benproteser Sverige;

    Sammanfattning : The aim of this dissertation study is to explore what it meant to thirteen persons to grow up with severe limb deficiencies (due to Thalidomide) and under the extreme life-conditions that indirectly became the consequences of their impairments. Aspects discussed concern:- The functional, social and psychological value of artificial legs from early childhood to grown up age seen from the persons' own perspective. LÄS MER

  7. 5. Leishmania and HIV-1 interaction : immunopathogenic mechanisms

    Författare :Dawit Wolday; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Both Leishmania and HIV can infect and multiply in macrophages, and both can dysregulate the T-helper (Th) immune system. This thesis was, therefore, undertaken to unravel some of the underlying immunopathogenic mechanisms of the interaction of the two pathogens. LÄS MER