Sökning: "stereospecific assay"

Hittade 3 avhandlingar innehållade orden stereospecific assay.

  1. 1. Pharmacokinetics of the enantiomers of thalidomide

    Författare :Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER

  3. 2. Opioid ligands and receptors of the joint

    Författare :Jonas Bergström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Opioid peptides; enkephalin; opioid receptors; joint; primary afferents; synovial lining cells; vascular smooth muscle; arthritis; osteoarthrosis; immunohistochemistry; radioimmunoassay; RTPCR; binding assay;

    Sammanfattning : The aim was to explore the occurrence of an opioid system in joints. Thus, joint tissues from rats with and without arthritis and also from patients with knee osteoarthrosis were investigated by EM, immunohistochemistry, RIA, HPLC, receptor binding assay and RT-PCR. LÄS MER

  4. 3. Catalytic mechanisms and evolution of leukotriene A4 hydrolyse

    Författare :Fredrik Tholander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammation is the first response of the body to infection or physical irritation. This response can potentially trigger the whole immune system but in the initial stage mainly involves leukocytes of the innate immune system and a complex cascade of chemical mediators, which by different means control, maintain and resolve the process. LÄS MER