Sökning: "hydroxylated metabolites"
Visar resultat 1 - 5 av 18 avhandlingar innehållade orden hydroxylated metabolites.
1. Pharmacokinetics of the enantiomers of thalidomide
Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER
2. Assessment of Environmental Pollutants in Humans from Four Continents : Exposure levels in Slovakia, Guinea-Bissau, Nicaragua and Bangladesh
Sammanfattning : Humans are continuously exposed to complex mixtures of anthropogenic chemicals. This thesis focus on human exposure to persistent organic pollutants (POPs). POPs ability to bioaccumulate and biomagnify together with the extensive historical use of POPs in e.g. LÄS MER
3. Synthesis of organobromines as a tool for their characterisation and environmental occurrence assessment
Sammanfattning : Polybrominated diphenyl ethers (PBDEs) have been intensively used as flame retardants (FRs) and have become ubiquitous environmental pollutants. PBDEs form hydroxylated PBDEs (OH-PBDEs) as metabolites. Further, some OH-PBDEs and methoxy-PBDEs (MeO-PBDEs) are natural products. LÄS MER
4. Identification and Characterisation of Hydroxylated PCB and PBDE Metabolites in Blood : Congener specific synthesis and analysis
Sammanfattning : Hydroxylated polychlorinated biphenyls (OH-PCBs) are known metabolites of polychlorinated biphenyls (PCBs) in many mammalian, bird and fish species. Among those, certain OH-PCB congeners are strongly localised in the blood compartment of humans and wild animals. LÄS MER
5. Exposure and effects of naturally produced hydroxylated polybrominated diphenyl ethers in fish : Implications for Baltic Sea wildlife
Sammanfattning : The aim of this thesis was to investigate if naturally produced hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are causing negative health effects for Baltic Sea wildlife. In the laboratory, OH-PBDEs have shown to be potent disrupters of energy metabolism as well as endocrine disruptors and neurotoxins. LÄS MER