Sökning: "IPSS"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet IPSS.

1. 1. Studies of anemia in the myelodysplastic syndromes

   Författare :Martin Jädersten; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Myelodysplasia; growth factors; Cox regression; delayed entry; left truncation; mortality; international prognostic scoring system; IPSS; who-classification based prognostic scoring system; WPSS; thalidomide analogue; IMiD; hematopoietic stem cell; adhesion; stroma; matrix; osteonectin; matricellular protein; NPM1; immunohistochemistry.;

   Sammanfattning : Background: The myelodysplastic syndromes (MDS) constitute a heterogeneous group of malignant bone marrow disorders, characterized by chronic anemia and increased risk of transformation to acute myeloid leukemia (AML). The first line therapy of anemia in MDS is erythropoietin (EPO) with or without granulocyte colony-stimulating factor (G-CSF). LÄS MER

3. 2. Population-based studies in Myelodysplastic syndromes : Prognostic scores, socioeconomic status, and therapy-related disease

   Författare :Daniel Moreno Berggren; Elisabeth Ejerblad; Sören Lehmann; Martin Jädersten; David Bowen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Myelodysplastic syndromes; Chronic myelomonocytic leukaemia; Prognostication; Comorbidity; Therapy-related disease; Real-world data; Population-based studies; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The aim of this thesis was to expand the epidemiological knowledge of the haematological malignancy MDS and the related condition chronic myelomonocytic leukaemia (CMML). Using nationwide registers, the papers in this thesis address aspects of prognostication, comorbidity, socioeconomic status, and therapy-related disease, using a population-based approach. LÄS MER

4. 3. Improving prognostication for patients with myelodysplastic syndromes

   Författare :Maria Creignou; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background and aims: MDS constitute a heterogenous group of myeloid malignancies mainly characterized by dysfunctional hematopoiesis. Although cytopenia, dysplastic features and evidence of clonality are essential criteria for the diagnosis of all MDS, the several subtypes of the disease have a highly variable prognosis. LÄS MER

5. 4. Transurethral resection of the prostate : how to reduce morbidity

   Författare :Tim Fagerström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Transurethral resection of the prostate (TURP) is the gold standard method for surgical treatment of benign prostatic hypertrophy. Despite the more recent introduction of medical therapies for benign prostatic hypertrophy (BPH), the high efficacy of TURP still makes it one of the most common surgical operations worldwide and approximately 6,000 such operations are performed every year in Sweden. LÄS MER

7. 5. Bloody big data : ensuring the health of blood donors and transfused patients with health registers

   Författare :Jingcheng Zhao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Blood transfusion is widely considered a pillar of modern medicine and is one of the most common medical interventions. A transfusion intimately links two persons and their health through the altruism of blood donors. In turn, this has necessitated the development of rigorous safety measures for both donors and recipients. LÄS MER