Sökning: "intravenous administration"

Visar resultat 1 - 5 av 91 avhandlingar innehållade orden intravenous administration.

1. 1. Pharmacokinetics of the enantiomers of thalidomide

   Författare :Tommy Eriksson; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein binding; blood distribution; stereoselective pharamacokinetics; pharmacokinetic modelling; oral administration; intravenous administration; chiral inversion; stereospecific assay; HPLC; Thalidomide; hydroxylated metabolites; enantiomers; in vitro kinetics; sedative effects; concentration-effect relationship.; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER

3. 2. Nasal administration of compounds active in the central nervous system : Exploring the olfactory system

   Författare :Maria Dahlin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; Nasal administration; olfactory pathway; cerebrospinal fluid; autoradiography; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

   Sammanfattning : The nasal administration of drugs offers advantages over administration by intravenous injection. Drugs can be rapidly absorbed through the nasal mucosa, resulting in a rapid onset of action, and also avoiding degradation in the gastrointestinal tract and first-pass metabolism in the liver. LÄS MER

4. 3. Pain induced by propofol - clinical studies on drug composition and adminstration

   Författare :Elisabeth Liljeroth; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intravenous; Medicin människa och djur ; Medicine human and vertebrates ; pain; propofol; injection;

   Sammanfattning : Over the last 25 years a number of new anaesthetic drugs have been introduced on the market to allow for better patient satisfaction and faster recovery after anaesthesia and sedation. Propofol (2,6-di-isopropylphenol), one of our most common iv anaesthetics, is associated with pleasant sleep and rapid recovery with little postoperative nausea. LÄS MER

5. 4. Intravenous contrast media optimization at computed tomography

   Författare :Anders Svensson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The administration of intravenous contrast media (IV CM) is essential for detecting lesions at most computed tomography (CT) examinations. The overall aim of this thesis is to investigate different aspects of IV CM administration that may affect the quality of the CT examination. LÄS MER

7. 5. Optimization of intravenous contrast media at computed tomography

   Författare :Anders Svensson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The administration of intravenous contrast media (IV CM) is essential for detecting lesions at most computed tomography (CT) examinations. The overall aim of this thesis is to investigate different aspects of IV CM administration that may affect the quality of the CT examination. LÄS MER