Sökning: "sedative effects"
Visar resultat 1 - 5 av 23 avhandlingar innehållade orden sedative effects.
1. Allopregnanolone effects in women : clinical studies in relation to the menstrual cycle, premenstrual dysphoric disorder and oral contraceptive use
Sammanfattning : Background: Premenstrual dysphoric disorder (PMDD) affects 3–8% of women in fertile ages. Combined oral contraceptives (OCs) are widely used and some users experience adverse mood effects. The cyclicity of PMDD symptoms coincides with increased endogenous levels of allopregnanolone after ovulation. LÄS MER
2. Pharmacokinetics of the enantiomers of thalidomide
Sammanfattning : Thalidomide has a chiral center and the racemate of (+)-(R) and (-)-(S)-thalidomide was introduced as a hypnotic/sedative drug in 1957. In 1961 it was withdrawn due to teratogenicity and neuropathy. There is a growing interest in thalidomide treatment of immunomodulatory diseases. LÄS MER
3. Behavioral effects of female sex steroid hormones : models of PMS and PMDD in Wistar rats
Sammanfattning : Background Animal models can be used to mimic human conditions of psychopathology, and also as pre-clinical models to evaluate candidate drugs. With hormonal treatment it is possible to produce behavior in the rat which corresponds to the mental symptoms of pre-menstrual syndrome (PMS), and pre-menstrual dysphoric disorder (PMDD). LÄS MER
4. Novel Psychoactive Substances : Experienced effects, attitudes, and motivations among online drug community users
Sammanfattning : The aim of the present research is to contribute to the bridging of the knowledge gap pertaining to the field of Novel Psychoactive Substances (NPS) and its online community of users. The findings demonstrate that the community is characterized by robust group cohesiveness and counter public attitudes. LÄS MER
5. “Dr Jekyll and Mr Hyde?” : Abuse of potent benzodiazepines, exemplified by flunitrazepam, in mentally disordered male offenders
Sammanfattning : Flunitrazepam (FZ) is an example of a sedative-hypnotic benzodiazepine whose pharmacokinetic properties include a rapid onset of action and an intermediate duration of action. It has a high affinity to central benzodiazepine receptors and affects them profoundly. LÄS MER