Sökning: "telomerase activity"

Visar resultat 21 - 25 av 44 avhandlingar innehållade orden telomerase activity.

  1. 21. Molecular Mechanisms in Endothelial Cell Differentiation

    Författare :Emma Rennel; Pär Gerwins; Lena Claesson-Welsh; Ian Zachary; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; angiogenesis; FGF-2; VEGF-A; signal transduction; in vitro angiogenesis assay; immortalized brain endothelial cells; H-Ras; tetracycline-regulated gene expression; microarray; telomerase immortalized human microvascular endothelial cells; differentiation; Patologi; Pathology; Patologi;

    Sammanfattning : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. LÄS MER

  3. 22. The nuclear factor k[kappa]B signal transduction pathway : its role in atherogenesis and intimal hyperplasia

    Författare :De-xiu Bu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; intimal hyperplasia; NF-kappaB; NGAL; Telomerase; Leukotriene B4;

    Sammanfattning : Vascular inflammation is a hallmark of major cardiovascular diseases such as atherosclerosis, and also suggested as a critical component implicated in intimal hyperplasia. Given its central role in regulating expression of inflammatory genes, the nuclear factor kappaB (NF-kappaB) signal transduction pathway was postulated to play an important role in these pathological processes. LÄS MER

  4. 23. Indicators of apoptosis and proliferation in haematological malignancies : with special reference to drug resistance and prognosis

    Författare :Barbara MacNamara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute Myeloid Leukaemia; Non-Hodgkin s Lymphoma Drug Resistance; Predictive Factor; International Prognostic Index; Apoptosis; Proliferation; Telomerase; BCL-2; BAX; p53;

    Sammanfattning : Successful treatment of acute myeloid leukaemia (AML) and high-grade non-Hodgkin's lymphoma (HG- NHL) is hampered by development of drug resistance. A better understanding of mechanisms responsible for drug resistance and the identification of factors that predict response to therapy is essential to improve treatment. LÄS MER

  5. 24. Molecular and cytogenic studies of oncogene alterations in human breast and cervical carcinomas

    Författare :Anju Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cancer; cervical cancer; oncogene; gene amplification; hTERT;

    Sammanfattning : Characterization of human tumors with associated genetic changes is of importance for better understanding the tumor's basic biological behavior and of great value for clinical management of cancer patients. We therefore investigated oncogene amplifications in human breast and cervical carcinomas using molecular and cytogenetic methods, especially FISH. LÄS MER

  7. 25. PARN – The Tail End : Function and mechanisms of specificity and processivity

    Författare :Mikael Nissbeck; Anders Virtanen; Renée Schroeder; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Poly A specific ribonuclease; Adenosine; Specificity; Processivty; Telomere biology disorders; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Poly(A)-specific ribonuclease (PARN) is an exoribonuclease that is processive, poly(A) specific and cap-binding. PARN deadenylates the poly(A) tails present on a subset of mRNAs and non-coding RNAs, including among others certain snoRNAs, miRNAs and precursor rRNAs. LÄS MER