Sökning: "H-Ras"

Visar resultat 1 - 5 av 8 avhandlingar innehållade ordet H-Ras.

  1. 1. Molecular Mechanisms in Endothelial Cell Differentiation

    Författare :Emma Rennel; Pär Gerwins; Lena Claesson-Welsh; Ian Zachary; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; angiogenesis; FGF-2; VEGF-A; signal transduction; in vitro angiogenesis assay; immortalized brain endothelial cells; H-Ras; tetracycline-regulated gene expression; microarray; telomerase immortalized human microvascular endothelial cells; differentiation; Patologi; Pathology; Patologi;

    Sammanfattning : Angiogenesis is the formation of new blood vessels from the pre-existing blood vessels. Blood vessels are composed of endothelial cells and supporting musculature. Angiogenesis is regulated by numerous soluble ligands and by cell-matrix interactions. LÄS MER

  3. 2. Ribosome display for selection and evolution of affibody molecules

    Författare :Sebastian Grimm; Per-Åke Nygren; Mike Taussig; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Sammanfattning : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. LÄS MER

  4. 3. Affinity protein based inhibition of cancer related signaling pathways

    Författare :Erik Vernet; Torbjörn Gräslund; Antonino Cattaneo; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; cancer; endoplasmic reticulum retention; EGFR; HER2; IGF-1R; Raf; Ras; Bioengineering; Bioteknik;

    Sammanfattning : Dysregulation of protein activity, caused by alterations in protein sequence, expression, or localization, is associated with numerous diseases. In order to control the activity of harmful protein entities, affinity ligands such as proteins, oligonucleotides or small molecules can be engineered to specifically interact with them to modulate their function. LÄS MER

  5. 4. The Importance of Isoprenylation and Nf1 Deficiency in K-RAS-induced Cancer

    Författare :Anna-Karin Sjögren; Göteborgs universitet; []
    Nyckelord :FTase; GGTase-I; isoprenylation; K-RAS; NF1; CAAX proteins; lung cancer; AML;

    Sammanfattning : The RAS and RHO family proteins contribute to tumorigenesis and metastasis and belong to a family of so called CAAX proteins. The membrane targeting and proper function of CAAX proteins are dependent on posttranslational isoprenylation by farnesyltransferase (FTase) or geranylgeranyltransferase type I (GGTase-I). LÄS MER

  7. 5. Effect of genetic polymorphisms on urinary bladder neoplasms

    Författare :Somali Sanyal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :urinary bladder neoplasms; polymorphisms; metabolism; DNA repair; cell-cycle regulation;

    Sammanfattning : Urinary bladder neoplasms (UBNs) are among the most common malignancies in the world and are mainly attributed to exogenous risk factors such as, smoking, exposure to industrial aromatic amines and certain medicinal drugs which cause DNA damage. The entire process leading to DNA damage and subsequent repair of the damage involves a plethora of enzymes including those involved in metabolic and DNA repair processes. LÄS MER