Sökning: "telomerase activity"

Visar resultat 11 - 15 av 44 avhandlingar innehållade orden telomerase activity.

  1. 11. Oncogenic Pathways and Molecular Prognostics in Neuroblastoma

    Författare :Kristoffer von Stedingk; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neuroblastoma; Prognostics; Telomerase; snoRNP; miR-17-92; TGF-β; Notch; Hypoxia; Angiogenesis;

    Sammanfattning : Neuroblastoma is an embryonal malignancy that accounts for 15% of all cancer related deaths amongst children. Although the overall survival of patients has been improving over the last decades, the high-risk neuroblastoma patients have a survival rate of ... LÄS MER

  3. 12. Development of adenoviral vectors for monitoring telomerase activity in living cells

    Författare :Anna Edqvist; Neurokirurgi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytogenetics; Genetics; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; GBM; HSC; adenovirus; hTERT; Genetik; cytogenetik;

    Sammanfattning : ABSTRACT Telomerase activity is a potential molecular marker for cancer and primitive cells in regenerative tissues. The most commonly used method to measure telomerase activity in cells is the telomerase reverse amplification protocol (TRAP) assay, where the protein extracts derived from homogenized cells are analysed. LÄS MER

  4. 13. Telomerase in hematological and other malignancies : therapeutic implications

    Författare :Bingnan Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Telomere is a nucleoprotein complex consisting of TTAGGG repeated sequences covered by specialized binding proteins termed shelterins masking the end of linear chromosomes and thereby protecting the end of the chromosome from genomic instability. Telomeres become progressively shortened during cellular replication and acts as a mitotic clock to confer a limited lifespan to normal cells. LÄS MER

  5. 14. Telomerase activation and its clinical implications in human thyroid tumors

    Författare :Na Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Telomerase is a ribonucleoprotein enzyme. The catalytic and rate-limiting component of telomerase is referred to as telomerase reverse transcriptase (TERT) that plays an important role in telomere maintenance, cell immortalization and malignant transformation. LÄS MER

  7. 15. Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation

    Författare :Cheng Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various physiological and pathophysiological activities including inflammation, apoptosis, cell maturation and tumorigenesis. LÄS MER