Sökning: "Acute Myeloid Leukaemia"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden Acute Myeloid Leukaemia.

1. 1. Modeling normal and malignant hematopoiesis in vitro. To screen for extrinsic regulators and differentiation therapy

   Författare :Simon Hultmark; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acute myeloid leukaemia; Hematologi; stem cells; differentiation induction; leukaemia; treatment; small molecule drugs; PKC; FLT3; shRNA; small molecule inhibitor; Small Molecule Libraries; MEK ERK pathway; natural product; co-culture; drug screening; combination therapy;

   Sammanfattning : The incredible thing with blood stem cells, also known as hematopoietic stem cells (HSC), is that they can restore normal hematopoiesis in patients that need a new blood system. Since a prerequisite for successful transplantation is immune compatibility, it requires large donor registries to find a suitable match for a recipient. LÄS MER

3. 2. Characterisation of the leukaemia-associated ETO homologues

   Författare :Sofia Rondin Lindberg; Avdelningen för hematologi och transfusionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; SIN3B; corepressor; MTGR1; MTG16; ETO; AML1-ETO; AML; haematopoiesis; leukaemia; Hematologi; extracellulära vätskor;

   Sammanfattning : Acute myeloid leukemia (AML) is commonly associated with balanced chromosomal translocations. Characteristically, these translocations lead to the fusion of two unrelated genes, resulting in the expression of an aberrant fusion protein. t(8;21) is one of the most common translocations found in patients with AML. LÄS MER

4. 3. Improving prognostication and treatment choices for patients with AML

   Författare :Albin Österroos; Sören Lehmann; Marc H G P Raaijmakers; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukaemia; Acute promyelocytic leukaemia; Prognostication; Personalised medicine; Risk stratification; Real-world data; Next-generation sequencing; Azacitidine; Venetoclax; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The treatment landscape of the aggressive haematological malignancy acute myeloid leukaemia (AML) has expanded but the prognosis is still unsatisfactory poor. Here, we aimed at improving prognostication and treatment choices in AML by addressing current clinical obstacles to successful AML treatment. LÄS MER

5. 4. Experimental studies on multidrug resistance in human leukaemia : role of cellular heterogeneity for daunorubicin kinetics

   Författare :Eva Knaust; Curt Peterson; Anna Porwit-MacDonald; Astrid Gruber; Christer Paul; Linköpings universitet; []
   Nyckelord :Acute myeloid leukaemia; heterogeneity; multidrug resistance. transport kinetics flow cytometry; gene expression; mdr1; mrp; lrp; apoptosis. bcl-2; p53; MEDICINE; MEDICIN;

   Sammanfattning : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myeloid leukaemia (AML) and still the majority of the patients die from their disease. Drug resistance 1s multifactorial, the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (Pgp). LÄS MER

7. 5. Regulation of tissue factor expression in myeloid and monocytic leukaemia cells

   Författare :Taavo Tenno; Uppsala universitet; []
   Nyckelord :Medical sciences; tissue factor; blood coagulation; monocytes; cell differentiation; retinoic acid; vitamin D3; acute promyelocytic leukaemia; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Clinical Chemistry; klinisk kemi;

   Sammanfattning : Tissue factor (TF) is a transmembrane glycoprotein that initiates the blood coagulation cascade and is also involved in cell migration, tumour metastasis and angiogenesis. Pathologic expression of tissue factor by monocytes contributes to several thrombotic complications like acute coronary artery disease and disseminated intravascular coagulation. LÄS MER