Sökning: "syntaxin"

Visar resultat 21 - 25 av 27 avhandlingar innehållade ordet syntaxin.

  1. 21. Proteins regulating vesicular docking and fusion : histochemical studies on their presence and regulation in endocrine, neuroendocrine and neuronal cells

    Författare :Gunilla Jacobsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :- axotomy; botulinum neurotoxin; cranial nerve; CSP; ECL; endocrine; estrogen; exocytosis; hypothalamus; immunohistochemistry; in situ hybridization; motoneuron; mouse; mRNA; munc-18; pancreas; parasympathetic; pituitary; rat; salt-loading; sciatic n;

    Sammanfattning : Regulated transmitter release involves docking and fusion of transmitter-containing vesicles with the plasma membrane. Vesicular docking and fusion events are mediated by specific exocytotic proteins located at the vesicle membrane, in the cytoplasm or at the plasma membrane. LÄS MER

  3. 22. Aspects on the modulation of potassium channels in insulin-producing beta-cells

    Författare :Zuheng Ma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :islets of Langerhans; over-stimulation; diazoxide; exocytosis; proteasome; microarray; Kv1.1.;

    Sammanfattning : This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits glucose-induced insulin secretion, was used as a probe. LÄS MER

  4. 23. Pancreatic beta-cell insulin signaling in genetic and dietary models of obesity and insulin resistance

    Författare :Meike Paschen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 Diabetes Mellitus (T2DM) is a heterogeneous metabolic disease characterized by elevated blood glucose levels that has reached pandemic proportions. Genome-wide association studies have linked T2DM to the function of the insulin-producing pancreatic βcell residing in the micro-organ islet of Langerhans. LÄS MER

  5. 24. Components controlling vesicle trafficking and regulated exocytosis in pancreatic beta-cells

    Författare :Slavena Andrea Mandic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regulated exocytosis is a sophisticated, well-organized and conserved multistage process underlying release of both neurotransmitters and hormones. Exocytosis is mediated by SNARE proteins that act at the center stage by forming a SNARE complex with the intrinsic capability to execute membrane fusion. LÄS MER

  7. 25. Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis

    Författare :Jones Ofori; Diabetes - öcellsexocytos; []
    Nyckelord :T2D; insulin secretion; exocytosis; ncRNAs; GAS5; miR-152; miR-335; miR-130a b; miR-375; STXBP1; SNAP25; SYT13; PDHA1; PDX1; glucocortiocoid; beta cell function; glucose metabolism;

    Sammanfattning : Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. LÄS MER