Sökning: "over-stimulation"

Hittade 4 avhandlingar innehållade ordet over-stimulation.

  1. 1. Effects of over-stimulation by glucose on pancreatic beta-cell functioning : studies in vitro with diazoxide

    Författare :Anneli Björklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :diabetes mellitus; diazoxide; hyperglycemia; insulin secretion; islets of Langerhans; over-stimulation;

    Sammanfattning : Long term hyperglycemia impairs pancreatic ß-cell function. In vivo studies in rats have shown a decreased glucose-induced insulin response in the perfused pancreas after high glucose infusions. LÄS MER

  3. 2. Aspects on the modulation of potassium channels in insulin-producing beta-cells

    Författare :Zuheng Ma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :islets of Langerhans; over-stimulation; diazoxide; exocytosis; proteasome; microarray; Kv1.1.;

    Sammanfattning : This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits glucose-induced insulin secretion, was used as a probe. LÄS MER

  4. 3. Inflammation, kinins, and kinin receptors

    Författare :Sara Bengtson; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Evidence is accumulating that the pathogenesis of many diseases is triggered by inappropriate inflammatory responses. These serious complications may occur when the tightly regulated inflammatory network is out of balance and it is now clear that this can eventually cause substantial harm to own cells and tissues. LÄS MER

  5. 4. Matrix metalloproteinase-26 (MMP-26) and Tissue inhibitor of metalloproteinases-4 (TIMP-4) in normal, hyperplastic, and malignant endometrium

    Författare :Radovan Pilka; Lund Obstetrik och gynekologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Obstetrics; gynaecology; Cytologi; onkologi; cancerology; secretion; Biology; Biologi; Cytology; oncology; implantation; human; endometrium; mRNA; MMP-26; TIMP-4; reproduktion; andrologi; gynekologi; Obstetrik; sexuality; reproduction; sexualitet; andrology;

    Sammanfattning : The aim of the thesis was to study matrix metalloproteinase-26 (MMP-26) and tissue inhibitor of metalloproteinases-4 (TIMP-4) in normal, hyperplastic, and malignant endometrium. Most importantnly, both these molecules may be ivolved in the implantation process. Trophoblast tissue from human as well as mouse embryos produces pro-MMP-9. LÄS MER