Sökning: "ncRNAs"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet ncRNAs.

  1. 1. RNA-mediated virulence gene regulation in the human pathogen Listeria monocytogenes

    Författare :Edmund Loh; Jörgen Johansson; Nancy Freitag; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Listeria monocytogenes; virulence; ncRNAs; PrfA; 5´-UTRs; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The Gram-positive human pathogen Listeria monocytogenes uses a wide range of virulence factors for its pathogenesis. The majority of its virulence genes are encoded on a 9-kb pathogenicity island and are controlled by the transcriptional activator PrfA. LÄS MER

  2. 2. Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis

    Författare :Jones Ofori; Diabetes - öcellsexocytos; []
    Nyckelord :T2D; insulin secretion; exocytosis; ncRNAs; GAS5; miR-152; miR-335; miR-130a b; miR-375; STXBP1; SNAP25; SYT13; PDHA1; PDX1; glucocortiocoid; beta cell function; glucose metabolism;

    Sammanfattning : Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. LÄS MER

  3. 3. Ancient roles of non-coding RNAs in eukaryotic evolution : contributions from social amoebae and other protists

    Författare :Lotta Avesson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : RNAs not coding for proteins, non-coding RNAs (ncRNAs) have many important roles in all kingdoms of life. Especially in eukaryotes, the regulatory functions of ncRNAs have been suggested as a major force in the evolution of complex traits. LÄS MER

  4. 4. Computational Approaches to the Identification and Characterization of Non-Coding RNA Genes

    Författare :Pontus Larsson; Anders Virtanen; Leif Kirsebom; Stephen Mount; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; Dictyostelium; nucleotide composition; partial sums; Bioinformatics; Bioinformatik;

    Sammanfattning : Non-coding RNAs (ncRNAs) have emerged as highly diverse and powerful key players in the cell, the range of capabilities spanning from catalyzing essential processes in all living organisms, e.g. protein synthesis, to being highly specific regulators of gene expression. LÄS MER

  5. 5. Regulation of gene expression by non-protein-coding RNAs

    Författare :Mohammad Ali Faghihi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. LÄS MER