Sökning: "syntaxin"

Visar resultat 16 - 20 av 27 avhandlingar innehållade ordet syntaxin.

  1. 16. Functional Studies of Genes Associated with Muscle Growth in Pigs and Hair Greying in Horses

    Författare :Lin Jiang; Leif Andersson; Kerstin Lindblad-Toh; Gerli Pielberg; Christopher Tuggle; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; QTN; muscle development; IGF2; ZBED6; RNA-seq; ChIP-seq; myoblasts; pancreatic beta cells; Grey horse; melanoma; MITF; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Sammanfattning : Domestic animals have become very different from their wild ancestors during domestication and animal breeding. This provides a good model to unravel the molecular mechanisms underlying phenotypic variation. In my thesis I have studied genes affecting two important traits, leanness in pigs and hair greying-associated melanoma in horses. LÄS MER

  3. 17. Interaction Between Mycobacterium tuberculosis and Human Neutrophils

    Författare :Nasrin Perskvist; Monica Thelestam; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Mycobacterium tuberculosis, the etiologic agent of tuberculosis, is responsible for more deaths each year than any other single pathogen. Mononuclear phagocytes and T cells are crucially involved in the control and local containment of this infection. Less is known about the contribution of neutrophils to control tuberculosis. LÄS MER

  4. 18. Studies of SNAP-25 in regulated membrane fusion : metabolic consequences and tuning of intracellular Ca(2+) dynamics in beta cells

    Författare :Teresa Daraio; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Increased release of insulin is usually regarded as a symptom of metabolic syndrome, contributing to insulin resistance in peripheral organs thus affecting glucose and insulin homeostasis. The existing animal models to address the metabolic syndrome are currently not optimal. LÄS MER

  5. 19. Pathophysiological effects of alpha-synuclein on SNARE complex proteins in models of alpha-synucleinopathies

    Författare :Emma Brolin; Joakim Bergström; Anna Erlandsson; Martin Ingelsson; Arianna Bellucci; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-synuclein; Parkinson’s disease; synaptosome; SNARE complex; proximity ligation assay; extracellular vesicles;

    Sammanfattning : Accumulation and spread of alpha-synuclein (α-syn) aggregates are central to the disease pathogenesis of Parkinson’s disease and dementia with Lewy bodies, collectively known as α-synucleinopathies. Native α-syn is a monomeric presynaptic protein that can act as a molecular chaperone for the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex assembly. LÄS MER

  7. 20. CFTR in pancreatic islets

    Författare :Anna Edlund; Diabetes - öcellsexocytos; []
    Nyckelord :CFTR; CF; CFRD; Cystic fibrosis; Cystisk fibros; Diabetes; Insulin; Beta cell; Glukagon; Glucagon; Alpha cell; Alfa-cell; Anoctamin; ANO1; ANO;

    Sammanfattning : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. LÄS MER