Sökning: "diazoxide"
Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet diazoxide.
1. Pulsatile insulin release from single islets of Langerhans
Sammanfattning : Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. LÄS MER
2. Effects of over-stimulation by glucose on pancreatic beta-cell functioning : studies in vitro with diazoxide
Sammanfattning : Long term hyperglycemia impairs pancreatic ß-cell function. In vivo studies in rats have shown a decreased glucose-induced insulin response in the perfused pancreas after high glucose infusions. LÄS MER
3. Aspects on the modulation of potassium channels in insulin-producing beta-cells
Sammanfattning : This thesis attempts to further clarify mechanisms behind the negative effects of overstimulation and the beneficial effect of β-cell rest. For this purpose diazoxide - opener of K+-ATP channels, which reversibly inhibits glucose-induced insulin secretion, was used as a probe. LÄS MER
4. The importance of immunological, genetic and clinical factors for beta cell function in childhood diabetes
Sammanfattning : Type I diabetes is caused by environmentally initiated, progressive autoimmune destruction of pancreatic beta cells in genetically susceptible individuals, which results in insulin deficiency and hyperglycemia. At diagnosis, about 10-20 % of beta cells remain, but after insulin therapy is started, a period with regained secretive capacity follows. LÄS MER
5. Endocrine aspects of obesity and weight reduction by bariatric surgery : with special emphasis on beta cell function
Sammanfattning : Severe obesity is the most predictive acquired risk factor for the development of type 2 diabetes. Bariatric surgery induces marked weight loss and reverses the diabetic state significantly. LÄS MER
