Sökning: "somatostatin receptors"

Visar resultat 36 - 40 av 44 avhandlingar innehållade orden somatostatin receptors.

  1. 36. Atopic dermatitis : aspects of defence defects

    Författare :Lena Hagströmer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atopic dermatitis (AD) is an inflammatory skin disease, typically with a chronic relapsing course and a defective skin barrier function. Recently, mutations of the skin barrier gene encoding filaggrin have been reported in a portion of the patients. In this thesis some aspects of defence defects in AD were studied. LÄS MER

  3. 37. Comparatative studies on the IGF system in vertebrates : studies in rats, and in bony, cartilaginous, and jawless fish

    Författare :Katarina Drakenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGF receptor; osteichthyes; chondrichthyes; cyclostomi; radioimmunoassay;

    Sammanfattning : Numerous studies have shown the importance of insulin-like growth factors (IGFs) for cellular growth, differentiation and metabolism in mammalian vertebrates. The mammalian IGF system, consists of IGF-1 and IGF-2, the IGF binding proteins (IGFBPs), and the type1 and type 2 IGF receptors. LÄS MER

  4. 38. Pharmacokinetics and dosimetry of radiolabelled octreotide for tumour therapy

    Författare :Peter Bernhardt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; radiation dosimetry; therapy; radionuclides; octreotide; neuroendocrine tumours; nude mice; patients;

    Sammanfattning : Somatostatin (SS) receptors (sstr) are usually highly expressed on neuroendocrine (NE) tumours. The radiolabelled SS analogue 111In-DTPA-D-Phe1-octreotide is today widely used to scintigraphically visualise NE tumours, and high 111In activity concentrations are obtained in tumour vs. normal tissues. LÄS MER

  5. 39. Evolution of the G protein-coupled receptor signaling system : Genomic and phylogenetic analyses

    Författare :Arunkumar Krishnan; Helgi Schiöth; Torgeir Hvidsten; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; GPCRs; G proteins; Sensory system; Signal transduction; Olfaction; Chemosensation; Hemichordates; Sponges; Porifera; Bilaterians; Holozoans; Fungi; Opisthokonts; Bioinformatics; Bioinformatik;

    Sammanfattning : Signal transduction pathways mediated by G protein-coupled receptors (GPCRs) and their intracellular coupling partners, the heterotrimeric G proteins, are crucial for several physiological functions in eukaryotes, including humans. This thesis describes a broad genomic survey and extensive comparative phylogenetic analysis of GPCR and G protein families from a wide selection of eukaryotes. LÄS MER

  7. 40. Targeted radionuclide therapy for patients with neuroendocrine tumours with focus on normal tissue response in 177-Lu-DOTATATE treatment

    Författare :Johanna Svensson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radionuclide therapy; Neuroendocrine tumours; 177Lu-DOTATATE; dosimetry; normal tissue response;

    Sammanfattning : Targeted radionuclide therapy with 177Lu-DOTATATE for patients with neuroendocrine tumours utilises the frequent overexpressing of somatostatin receptors on the tumour cells. This treatment modality has demonstrated valuable patient benefits and is well tolerated. However, renal and bone marrow toxicity can become dose limiting and persisting. LÄS MER