Sökning: "somatostatin receptors"

Visar resultat 41 - 44 av 44 avhandlingar innehållade orden somatostatin receptors.

  1. 41. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE

    Författare :Sara Lundsten; Marika Nestor; Hanna Björkelund; Katarina Edwards; Julie Nonnekens; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; targeted radionuclide therapy; radiosensitization; p53; MDM2 MDM4 inhibition; HSP90; drug synergy; drug delivery; lipid nanoparticles; lipodisks; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. LÄS MER

  3. 42. Neuropharmacological studies of Parkinson's disease with some emphasis on serotonin transmission

    Författare :Xiaoqun Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by hypokinesia, rigidity, tremor, gait disturbances and depression. There is an accumulative of protein aggregates, Lewy bodies, which appear to begin in the brainstem and progress caudorostrally. LÄS MER

  4. 43. Hippocampal galanin and acetylcholine in spatial learning

    Författare :Pär A Schött; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :hippocampus; galanin; acetylcholine; memory and learning; swim maze; microinjections; HPLC;

    Sammanfattning : The aim of the present thesis was to study how the neuropeptide galanin affects the neurochemistry and functional activity of the cholinergic septohippocampal projection, which plays a pivotal role in learning and memory. This cholinergic system is strongly impaired in Alzheimer's disease and in age-related dementias. LÄS MER

  5. 44. Receptor-operated signaling pathways in normal and diabetic pancreatic islet cell function

    Författare :Fan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Loss of glucose-dependent insulin release is an early pathogenetic event in human type 2 diabetes. Impaired glucose-mediated insulin secretion from pancreatic islet β-cells leads to insulin deficiency and thus hyperglycemia. LÄS MER