Sökning: "small GTPase"

Visar resultat 1 - 5 av 30 avhandlingar innehållade orden small GTPase.

  1. 1. Anaplastic Lymphoma Kinase mutations and downstream signalling

    Författare :Christina Schönherr; Ruth H Palmer; Aristidis Moustakas; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Anaplastic Lymphoma Kinase; oncogene; RTK; neuroblastoma; crizotinib; NVP-TAE684; gain-of-function; MYCN; transcription factor; small GTPase; Rap1; C3G; PC12 cells; neurite outgrowth; molecular cell biology; molekylär cellbiologi;

    Sammanfattning : The oncogene Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and was initially discovered as the fusion protein NPM (nucleophosmin)-ALK in a subset of Anaplastic Large Cell Lymphomas (ALCL). Since then more fusion proteins have been identified in a variety of cancers. LÄS MER

  3. 2. Cytoskeletal Regulation During Embryonic Development in Drosophila melanogaster

    Författare :Mojgan Padash; Udo Häckers grupp Utvecklingsbiologi i invertebrater; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Naturvetenskap; Natural science; DRhoGEF2; Actin cytoskeleton; Rho GTPase;

    Sammanfattning : The development of multicellular organisms is associated with extensive rearrangements of cells and tissues. The driving force for these rearrangements is generated by the cell's actin cytoskeleton. During many morphogenetic processes dynamic rearrangement of the actin cytoskeleton is regulated by small GTPases of the Rho-family. LÄS MER

  4. 3. Signal Transduction in Malignant Cells – Transformation, Activation and Differentiation

    Författare :Karin Kårehed; Fredrik Öberg; Jan-Ingvar Jönsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; transformation; PDGF; PI3K; Rho-GTPase; U-937; FcγRI; macrophage; Stat1; PKR; NFκB; ATRA; differentiation; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Pathology; Patologi;

    Sammanfattning : All aspects of cell life are regulated by signal transduction mechanisms. This thesis describes the regulatory roles of a few key signal transduction molecules involved in three major biological responses. LÄS MER

  5. 4. Exoenzyme S of Pseudomonas aeruginosa : cellular targets and interaction with 14-3-3

    Författare :Lubna Yasmin; Bengt Hallberg; Joan Olson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ExoS; ADP-ribosylation; 14-3-3 protein; Pseudomonas aeruginosa; Small GTPases; RAS; RAP; Pathology; Patologi;

    Sammanfattning : Pseudomonas aeruginosa is an opportunistic pathogen that is a serious problem for immuno-compromised patients. Toxins such as exoenzyme (Exo) S, ExoT, ExoY and ExoU are secreted and translocated from the bacteria into the eukaryotic cell via the bacterial encoded type III secretion system. LÄS MER

  7. 5. Synthesis and investigation of bacterial effector molecules

    Författare :Michael Franz Albers; Christian Hedberg; Christian Hackenberger; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bacterial effectors; organic synthesis; Legionella; PTM; peptide synthesis; nucleotide chemistry; Biorganic Chemistry; bioorganisk kemi;

    Sammanfattning : During infections, bacterial microorganisms initiate profound interactions with mammalian host cells. Usually defense mechanisms of the host destroy intruding bacteria in rapid manner. However, many bacterial pathogens have evolved in a way to avoid these mechanisms. LÄS MER